Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 14/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ACACB | O00763 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22941968 | 0.87 | ALDH1A1 (0.43) | ALDH1A1MAPK1HTTOPRK1JAK2 | |
| SCHEMBL29969605 | 0.85 | AAK1 (0.37) | ALDH1A1MAPK1HTTOPRK1ACACB | |
| SCHEMBL29969671 | 0.82 | ALDH1A1 (0.40) | ALDH1A1MAPK1HTTOPRK1MEN1 | |
| SCHEMBL26127971 | 0.82 | ALDH1A1 (0.40) | ALDH1A1MAPK1HTTOPRK1MEN1 | |
| SCHEMBL26129799 | 0.81 | OPRK1 (0.39) | OPRK1ACACB | |
| SCHEMBL26130781 | 0.80 | JAK2 (0.43) | ALDH1A1MAPK1HTTOPRK1JAK2 | |
| SCHEMBL29968129 | 0.80 | JAK2 (0.43) | ALDH1A1MAPK1HTTOPRK1JAK2 | |
| SCHEMBL27154515 | 0.79 | OPRK1 (0.41) | ALDH1A1MAPK1HTTOPRK1POLB | |
| SCHEMBL29969938 | 0.79 | ALDH1A1 (0.40) | ALDH1A1MAPK1HTTOPRK1MEN1 | |
| SCHEMBL26131044 | 0.79 | ALDH1A1 (0.40) | ALDH1A1MAPK1HTTOPRK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4327877-A2 | DUAL ATM AND DNA-PK INHIBITORS FOR USE IN ANTI-TUMOR THERAPY | XRad Therapeutics, Inc. (US) | 2024-02-28 | — | — | EP | disclosed |
| EP-3784671-B1 | DUAL ATM AND DNA-PK INHIBITORS FOR USE IN ANTI-TUMOR THERAPY | XRAD THERAPEUTICS INC (US) | 2023-10-11 | — | — | EP | disclosed |