Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | AKR1B10 | O60218 | 6/20 | 0.45 |
| ▸ | AKR1B1 | P15121 | 6/20 | 0.45 |
| ▸ | CA12 | O43570 | 2/20 | 0.45 |
| ▸ | CA4 | P22748 | 2/20 | 0.45 |
| ▸ | CA6 | P23280 | 2/20 | 0.45 |
| ▸ | CA5A | P35218 | 2/20 | 0.45 |
| ▸ | CA7 | P43166 | 2/20 | 0.45 |
| ▸ | CA9 | Q16790 | 2/20 | 0.45 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.45 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.45 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.44 |
| ▸ | TTR | P02766 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.39 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 2/20 | 0.37 |
| ▸ | MMP1 | P03956 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26130300 | 1.00 | LMNA (0.48) | LMNAAKR1B10AKR1B1CA12CA4 | |
| SCHEMBL30613310 | 0.89 | RAB9A (0.45) | LMNAAKR1B10AKR1B1CA12CA4 | |
| SCHEMBL26584249 | 0.77 | LMNA (0.49) | LMNAAKR1B10AKR1B1CA12CA4 | |
| SCHEMBL26584644 | 0.74 | LMNA (0.51) | LMNAAKR1B10AKR1B1CA12CA4 | |
| SCHEMBL21465417 | 0.69 | LMNA (0.57) | LMNAAKR1B10AKR1B1CA12CA4 | |
| SCHEMBL21465446 | 0.69 | LMNA (0.57) | LMNAAKR1B10AKR1B1CA12CA4 | |
| SCHEMBL4814225 | 0.69 | LMNA (0.60) | LMNAAKR1B10AKR1B1CA12CA4 | |
| SCHEMBL14107685 | 0.69 | LMNA (0.60) | LMNAAKR1B10AKR1B1CA12CA4 | |
| SCHEMBL13473879 | 0.68 | LMNA (0.58) | LMNAAKR1B10AKR1B1CA12CA4 | |
| SCHEMBL337503 | 0.68 | HCAR2 (0.89) | LMNAAKR1B10AKR1B1CA12CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023194895-A1 | PYRROL DERIVATIVES AS INHIBITORS OF APOLIPOPROTEIN L-1 | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2023-10-12 | — | — | WO | disclosed |