Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.45 |
| ▸ | NPC1 | O15118 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.41 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA4 | P22748 | 1/20 | 0.41 |
| ▸ | CA6 | P23280 | 1/20 | 0.41 |
| ▸ | CA5A | P35218 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | STAT1 | P42224 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26130300 | 0.89 | LMNA (0.48) | LMNAAKR1B10AKR1B1CA12CA4 | |
| SCHEMBL26130296 | 0.89 | LMNA (0.48) | LMNAAKR1B10AKR1B1CA12CA4 | |
| SCHEMBL26584249 | 0.73 | LMNA (0.49) | RAB9ANPC1LMNAAKR1B10AKR1B1 | |
| SCHEMBL26584644 | 0.70 | LMNA (0.51) | LMNAAKR1B10AKR1B1CA12CA4 | |
| SCHEMBL22747625 | 0.70 | TUBB4A (0.47) | KMT2ALMNAMAPTATMALOX15 | |
| SCHEMBL10505388 | 0.70 | LMNA (0.53) | RAB9ANPC1KMT2ALMNAAKR1B10 | |
| SCHEMBL10505396 | 0.70 | LMNA (0.53) | RAB9ANPC1KMT2ALMNAAKR1B10 | |
| SCHEMBL26130798 | 0.69 | KDM4E (0.46) | RAB9ANPC1LMNAMAPTPOLB | |
| SCHEMBL7617245 | 0.69 | HCAR2 (0.74) | LMNAAKR1B10AKR1B1CA12CA4 | |
| SCHEMBL7618935 | 0.69 | HCAR2 (0.74) | LMNAAKR1B10AKR1B1CA12CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023194895-A1 | PYRROL DERIVATIVES AS INHIBITORS OF APOLIPOPROTEIN L-1 | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2023-10-12 | — | — | WO | disclosed |