Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.35 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.35 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.35 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.35 |
| ▸ | TPMT | P51580 | 2/20 | 0.35 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.33 |
| ▸ | ERN1 | O75460 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30413667 | 1.00 | MAPT (0.43) | MAPTGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL31347289 | 0.78 | MAPT (0.46) | MAPTGPR35SMN1; SMN2HTTALDH1A1 | |
| SCHEMBL3285272 | 0.78 | MAPT (0.49) | MAPTGPR35ERN1ALDH1A1LMNA | |
| SCHEMBL25246827 | 0.73 | GRIN2D (0.43) | MAPTGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL31683208 | 0.72 | GRIN2D (0.42) | MAPTGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL27190094 | 0.72 | CTSB (0.40) | MAPTTPMTGPR35ERN1SMN1; SMN2 | |
| SCHEMBL16475125 | 0.71 | KDM4E (0.37) | MAPTGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL30325942 | 0.70 | PDXK (0.35) | TPMTPOLB | |
| SCHEMBL21383944 | 0.70 | KMT2A (0.38) | MAPTGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL29947327 | 0.70 | KMT2A (0.38) | MAPTGRIN2DGRIN3BGRIN1GRIN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023066825-A1 | FUSED BICYCLIC HETEROARYL COMPOUNDS USEFUL AS NLRP3 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2023-04-27 | — | — | WO | disclosed |