Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 2/20 | 0.35 |
| ▸ | JAK3 | P52333 | 8/20 | 0.35 |
| ▸ | JAK2 | O60674 | 7/20 | 0.35 |
| ▸ | JAK1 | P23458 | 3/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | TYK2 | P29597 | 2/20 | 0.32 |
| ▸ | BTK | Q06187 | 2/20 | 0.32 |
| ▸ | LCK | P06239 | 1/20 | 0.32 |
| ▸ | SRC | P12931 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.31 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.31 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.30 |
| ▸ | METTL3 | Q86U44 | 2/20 | 0.30 |
| ▸ | EEF2K | O00418 | 1/20 | 0.30 |
| ▸ | FGR | P09769 | 1/20 | 0.30 |
| ▸ | EPHA1 | P21709 | 1/20 | 0.30 |
| ▸ | TXK | P42681 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26106044 | 0.85 | CCNT1 (0.38) | RETLRRK2PIK3CDBTKLCK | |
| SCHEMBL30582605 | 0.85 | CCNT1 (0.38) | RETLRRK2PIK3CDBTKLCK | |
| SCHEMBL30582601 | 0.84 | PIK3CD (0.40) | RETLRRK2PIK3CDSRCFGR | |
| SCHEMBL26105782 | 0.84 | PIK3CD (0.40) | RETLRRK2PIK3CDSRCFGR | |
| SCHEMBL26105963 | 0.83 | CCNT1 (0.34) | RETLRRK2PIK3CDSRCPRMT5 | |
| SCHEMBL30582633 | 0.83 | CCNT1 (0.34) | LRRK2PIK3CDSRCFGREPHA1 | |
| SCHEMBL26106109 | 0.83 | CCNT1 (0.34) | LRRK2PIK3CDSRCFGREPHA1 | |
| SCHEMBL30582608 | 0.83 | CCNT1 (0.34) | RETLRRK2PIK3CDSRCPRMT5 | |
| SCHEMBL26107963 | 0.83 | LRRK2 (0.34) | RETLRRK2 | |
| SCHEMBL30582544 | 0.83 | SRC (0.44) | PIK3CDLCKSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4499616-A1 | SPIROBICYCLIC COMPOUNDS | Acerand Therapeutics (Hong Kong) Limited (HK) | 2025-02-05 | — | — | EP | disclosed |
| CN-119013260-A | Spirobicyclic compounds | 优领医药科技(香港)有限公司 | 2024-11-22 | — | — | CN | disclosed |
| WO-2023192502-A1 | SPIROBICYCLIC COMPOUNDS | ACERAND THERAPEUTICS (USA) LIMITED (US) | 2023-10-05 | — | — | WO | disclosed |