Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 1/20 | 0.34 |
| ▸ | ITK | Q08881 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 12/20 | 0.32 |
| ▸ | METTL3 | Q86U44 | 10/20 | 0.32 |
| ▸ | WDR77 | Q9BQA1 | 3/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.31 |
| ▸ | ABL1 | P00519 | 2/20 | 0.31 |
| ▸ | EGFR | P00533 | 2/20 | 0.31 |
| ▸ | HCK | P08631 | 2/20 | 0.31 |
| ▸ | SRC | P12931 | 2/20 | 0.31 |
| ▸ | KDR | P35968 | 2/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.31 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.31 |
| ▸ | MTOR | P42345 | 2/20 | 0.31 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.31 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.31 |
| ▸ | PRKDC | P78527 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26105963 | 1.00 | CCNT1 (0.34) | CCNT1CDK9ITKRETLRRK2 | |
| SCHEMBL31219399 | 0.86 | MAP4K4 (0.33) | RETLRRK2PRMT5METTL3WDR77 | |
| SCHEMBL26106044 | 0.85 | CCNT1 (0.38) | CCNT1CDK9RETLRRK2PIK3CD | |
| SCHEMBL30582605 | 0.85 | CCNT1 (0.38) | CCNT1CDK9RETLRRK2PIK3CD | |
| SCHEMBL26105782 | 0.85 | PIK3CD (0.40) | CCNT1CDK9RETLRRK2PIK3CD | |
| SCHEMBL30582601 | 0.85 | PIK3CD (0.40) | CCNT1CDK9RETLRRK2PIK3CD | |
| SCHEMBL26106008 | 0.84 | ITK (0.35) | ITKRETLRRK2EGFR | |
| SCHEMBL26587873 | 0.84 | ITK (0.49) | ITKEGFR | |
| SCHEMBL30582593 | 0.84 | KCNH2 (0.34) | CCNT1CDK9ABL1EGFRSRC | |
| SCHEMBL30582590 | 0.84 | KCNH2 (0.34) | CCNT1CDK9ABL1EGFRSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4499616-A1 | SPIROBICYCLIC COMPOUNDS | Acerand Therapeutics (Hong Kong) Limited (HK) | 2025-02-05 | — | — | EP | disclosed |
| CN-119013260-A | Spirobicyclic compounds | 优领医药科技(香港)有限公司 | 2024-11-22 | — | — | CN | disclosed |
| WO-2023192502-A1 | SPIROBICYCLIC COMPOUNDS | ACERAND THERAPEUTICS (USA) LIMITED (US) | 2023-10-05 | — | — | WO | disclosed |