Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 7/20 | 0.52 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.50 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.50 |
| ▸ | CDK1 | P06493 | 1/20 | 0.50 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.50 |
| ▸ | GSK3A | P49840 | 1/20 | 0.50 |
| ▸ | GSK3B | P49841 | 1/20 | 0.50 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.50 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.49 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | TNKS | O95271 | 1/20 | 0.44 |
| ▸ | GCGR | P47871 | 1/20 | 0.43 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26135942 | 0.91 | ERCC1 (0.47) | KIF11SCN2ACCNB2CDK1CCNB1 | |
| SCHEMBL10222198 | 0.85 | SCN2A (0.44) | KIF11SCN2ACCNB2CDK1CCNB1 | |
| SCHEMBL21686599 | 0.79 | KDM4E (0.62) | KIF11SCN2A | |
| SCHEMBL15614396 | 0.79 | ERCC1 (0.67) | KIF11SCN2ACCNB2CDK1CCNB1 | |
| SCHEMBL30989524 | 0.78 | RXRA (0.42) | KIF11SCN2ACCNB2CDK1CCNB1 | |
| SCHEMBL197238 | 0.78 | KIF11 (0.78) | KIF11ALDH1A1TSHR | |
| SCHEMBL29914837 | 0.78 | KIF11 (0.78) | KIF11ALDH1A1TSHR | |
| SCHEMBL13410633 | 0.78 | KIF11 (0.78) | KIF11ALDH1A1TSHR | |
| SCHEMBL31518178 | 0.76 | KIF11 (0.49) | KIF11PARP1 | |
| Hydrochloric Acid SCHEMBL30729484 | 0.75 | KIF11 (0.47) | KIF11PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023194895-A1 | PYRROL DERIVATIVES AS INHIBITORS OF APOLIPOPROTEIN L-1 | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2023-10-12 | — | — | WO | disclosed |
| WO-2023194895-A1 | PYRROL DERIVATIVES AS INHIBITORS OF APOLIPOPROTEIN L-1 | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2023-10-12 | — | — | WO | disclosed |