Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.56 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TLR2 | O60603 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23729802 | 0.95 | HPGD (0.51) | HPGDEPHX2ALDH1A1CYP3A4RAB9A | |
| SCHEMBL26700589 | 0.93 | HPGD (0.50) | HPGDEPHX2ALDH1A1CYP3A4RAB9A | |
| SCHEMBL26700591 | 0.93 | HPGD (0.50) | HPGDEPHX2ALDH1A1CYP3A4RAB9A | |
| SCHEMBL25977212 | 0.89 | HPGD (0.47) | HPGDEPHX2ALDH1A1CYP3A4RAB9A | |
| SCHEMBL26700602 | 0.83 | ALDH1A1 (0.50) | HPGDEPHX2ALDH1A1CYP3A4RAB9A | |
| SCHEMBL22447940 | 0.83 | HPGD (0.62) | HPGDEPHX2ALDH1A1CYP2D6CYP2C19 | |
| SCHEMBL23729880 | 0.82 | HPGD (0.43) | HPGDEPHX2ALDH1A1CYP3A4RAB9A | |
| SCHEMBL26700969 | 0.80 | HPGD (0.50) | HPGDALDH1A1CYP3A4RAB9ALMNA | |
| SCHEMBL13681686 | 0.79 | ALDH1A1 (0.44) | HPGDALDH1A1CYP3A4RAB9ADEGS1 | |
| SCHEMBL27251492 | 0.78 | FAAH (0.55) | HPGDALDH1A1CYP3A4RAB9ADEGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230348452-A1 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC. | 2023-11-02 | — | — | US | disclosed |
| US-20230150974-A1 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC. | 2023-05-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230150974-A1 | COMPOUNDS AND USES THEREOF | VHL, CLN6, TFEB | HPGD 3705/4885EPHX2 2919/4885ALDH1A1 2571/4885 |
| US-20230348452-A1 | COMPOUNDS AND USES THEREOF | VHL, CLN6, BRCA1 | HPGD 3620/4885EPHX2 2431/4885ALDH1A1 2600/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.