SCHEMBL26148805

SCHEMBL26148805

CC(C)(C)OC(=O)NC(C)(C)C(=O)OC[C@@H](OC#N)[C@@H](O)[C@@H](O)c1ccc2c(N)ncnn12

nearest known ligand 0.32

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ CSNK2A2 P19784 1/20 0.32
▸ CSNK2A1 P68400 1/20 0.32
▸ EGLN2 Q96KS0 3/20 0.32
▸ RIPK1 Q13546 1/20 0.30
▸ AAK1 Q2M2I8 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26148819 0.86 CTSK (0.36) CSNK2A2CSNK2A1EGLN2RIPK1
SCHEMBL26210833 0.83 RIPK1 (0.33) RIPK1
SCHEMBL26213445 0.78 RIPK1 (0.30) RIPK1
SCHEMBL26325771 0.76 — —
SCHEMBL26328104 0.76 EGLN2 (0.38) EGLN2
SCHEMBL26325783 0.76 — —
SCHEMBL26325789 0.75 — —
SCHEMBL26325762 0.75 — —
SCHEMBL24414215 0.73 — —
SCHEMBL20762554 0.73 RIPK1 (0.31) RIPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11814406-B2 Compounds and methods for treatment of viral infections GILEAD SCIENCES, INC. (US) 2023-11-14 — — US disclosed
US-20230151043-A1 COMPOUNDS AND METHODS FOR TREATMENT OF VIRAL INFECTIONS GILEAD SCIENCES, INC. 2023-05-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11814406-B2 Compounds and methods for treatment of viral infections HAVCR2, EIF2AK2, ACE CSNK2A2 3583/4885CSNK2A1 3684/4885EGLN2 1720/4885
US-20230151043-A1 COMPOUNDS AND METHODS FOR TREATMENT OF VIRAL INFECTIONS HAVCR2, EIF2AK2, ACE CSNK2A2 3583/4885CSNK2A1 3684/4885EGLN2 1720/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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