SCHEMBL26167656

SCHEMBL26167656

CC(=O)[C@@H](C)Cc1ccncc1

nearest known ligand 0.55

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 2/20 0.55
ALDH1A1 P00352 1/20 0.55
LMNA P02545 2/20 0.46
MAPT P10636 1/20 0.46
MAPK1 P28482 1/20 0.46
CYP19A1 P11511 2/20 0.45
CYP1A2 P05177 1/20 0.44
CYP2C9 P11712 1/20 0.44
CYP2C19 P33261 1/20 0.44
TBXAS1 P24557 2/20 0.44
TSHR P16473 1/20 0.43
HTT P42858 1/20 0.41
ACACB O00763 3/20 0.40
MAOB P27338 1/20 0.40
CHRM1 P11229 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14276781 1.00 CYP3A4 (0.55) CYP3A4ALDH1A1LMNAMAPTMAPK1
SCHEMBL9293068 0.85 ESR1 (0.48) CYP3A4LMNAMAPK1CYP2C9TBXAS1
SCHEMBL12939671 0.84 TBXAS1 (0.59) CYP3A4ALDH1A1LMNAMAPTMAPK1
SCHEMBL266479 0.84 TBXAS1 (0.59) CYP3A4ALDH1A1LMNAMAPTMAPK1
SCHEMBL7973325 0.82 CYP3A4 (0.54) CYP3A4ALDH1A1LMNAMAPTMAPK1
SCHEMBL1286079 0.82 CYP3A4 (0.54) CYP3A4ALDH1A1LMNAMAPTMAPK1
SCHEMBL14338226 0.80 HSD17B10 (0.47) CYP3A4ALDH1A1CYP19A1CYP1A2CYP2C9
SCHEMBL12992547 0.80 HSD17B10 (0.47) CYP3A4ALDH1A1CYP19A1CYP1A2CYP2C9
SCHEMBL14317338 0.80 HSD17B10 (0.47) CYP3A4ALDH1A1CYP19A1CYP1A2CYP2C9
SCHEMBL20126694 0.79 ALDH1A1 (0.55) CYP3A4ALDH1A1LMNAMAPTMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024059472-A1 MACROCYCLIC IMMUNOMODULATORS BRISTOL-MYERS SQUIBB COMPANY (US) 2024-03-21 WO disclosed
WO-2023225661-A1 MACROCYCLIC IMMUNOMODULATORS BRISTOL-MYERS SQUIBB COMPANY (US) 2023-11-23 WO disclosed
WO-2023102507-A1 MACROCYCLIC IMMUNOMODULATORS BRISTOL-MYERS SQUIBB COMPANY (US) 2023-06-08 WO disclosed