Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.55 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.42 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.42 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.41 |
| ▸ | ACACB | O00763 | 3/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2958476 | 0.84 | ALDH1A1 (0.50) | ALDH1A1CYP3A4CYP19A1MAPK1LMNA | |
| SCHEMBL5570673 | 0.84 | CYP3A4 (0.45) | ALDH1A1CYP3A4CYP19A1MAPK1LMNA | |
| SCHEMBL17761604 | 0.81 | ALDH1A1 (0.60) | ALDH1A1CYP3A4MAPK1MAPTCYP2C9 | |
| SCHEMBL517463 | 0.81 | ALDH1A1 (0.60) | ALDH1A1CYP3A4MAPK1MAPTCYP2C9 | |
| SCHEMBL2600694 | 0.81 | ALDH1A1 (0.60) | ALDH1A1CYP3A4MAPK1MAPTCYP2C9 | |
| SCHEMBL19699287 | 0.81 | ALDH1A1 (0.47) | ALDH1A1CYP3A4CYP19A1HSD17B10ESR1 | |
| SCHEMBL2059222 | 0.81 | ALDH1A1 (0.47) | ALDH1A1CYP3A4CYP19A1HSD17B10ESR1 | |
| SCHEMBL5401318 | 0.81 | ALDH1A1 (0.47) | ALDH1A1CYP3A4CYP19A1HSD17B10ESR1 | |
| SCHEMBL16508902 | 0.80 | TBXAS1 (0.57) | ALDH1A1CYP3A4LMNACYP2C9HSD17B10 | |
| SCHEMBL14590363 | 0.80 | ATM (0.50) | ALDH1A1CYP2C9CYP2C19THRBHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180127464-A1 | NOVEL EPHA4 INHIBITORS TARGETING ITS LIGAND BINDING DOMAIN | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE | 2018-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180127464-A1 | NOVEL EPHA4 INHIBITORS TARGETING ITS LIGAND BINDING DOMAIN | EPHA4, EPHA1, EPHA6 | ALDH1A1 3265/4885CYP3A4 2612/4885CYP19A1 4504/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.