Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALPG | P10696 | 2/20 | 0.48 |
| ▸ | PLAA | Q9Y263 | 1/20 | 0.48 |
| ▸ | ALPL | P05186 | 1/20 | 0.47 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA3 | P07451 | 1/20 | 0.37 |
| ▸ | CA4 | P22748 | 1/20 | 0.37 |
| ▸ | CA6 | P23280 | 1/20 | 0.37 |
| ▸ | CA5A | P35218 | 1/20 | 0.37 |
| ▸ | CA7 | P43166 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.37 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.37 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31713029 | 0.87 | TLR8 (0.50) | ALPGPLAAALPLTLR8ALDH1A1 | |
| SCHEMBL11295344 | 0.85 | KCNH2 (0.42) | ALPGPLAAALPLTLR8ALDH1A1 | |
| SCHEMBL17865370 | 0.83 | KCNH2 (0.41) | ALPGPLAAALPLTLR8ALDH1A1 | |
| SCHEMBL11618141 | 0.83 | — | — | |
| SCHEMBL4233920 | 0.83 | TLR8 (0.48) | ALPGPLAAALPLTLR8ALDH1A1 | |
| SCHEMBL31590567 | 0.82 | ALDH1A1 (0.47) | ALPGPLAAALPLTLR8ALDH1A1 | |
| SCHEMBL20425451 | 0.82 | KCNH2 (0.42) | ALPGPLAAALPLKCNH2FPR2 | |
| Bromide SCHEMBL28149514 | 0.82 | TLR8 (0.47) | ALPGPLAAALPLTLR8ALDH1A1 | |
| SCHEMBL23053790 | 0.80 | KCNH2 (0.33) | ALPGPLAAALPLTLR8ALDH1A1 | |
| SCHEMBL687272 | 0.80 | TLR8 (0.42) | ALPGPLAAALPLTLR8ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230279025-A1 | KRAS G12D INHIBITORS | ARRAY BIOPHARMA INC. | 2023-09-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230279025-A1 | KRAS G12D INHIBITORS | KRAS, NRAS, HRAS | ALPG 3968/4885PLAA 1874/4885ALPL 4241/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.