Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28036345 | 0.74 | — | — | |
| Water SCHEMBL27523789 | 0.72 | TSHR (0.43) | TSHR | |
| SCHEMBL28061423 | 0.71 | TSHR (0.34) | TSHR | |
| SCHEMBL24225951 | 0.69 | — | — | |
| SCHEMBL10611609 | 0.69 | — | — | |
| SCHEMBL28290246 | 0.65 | ALDH1A1 (0.43) | TSHR | |
| SCHEMBL28208167 | 0.65 | — | — | |
| SCHEMBL14141713 | 0.64 | POLB (0.39) | TSHR | |
| SCHEMBL5410203 | 0.64 | TSHR (0.40) | TSHR | |
| SCHEMBL2252591 | 0.64 | TSHR (0.40) | TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8133911-B2 | (R)-4-(heteroaryl) phenylethyl derivatives and pharmaceutical compositions containing them | DOMPE S.P.A (IT) | 2012-03-13 | — | — | US | disclosed |
| EP-2201006-B1 | (R)-4-(HETEROARYL) PHENYLETHYL DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | DOMPE SPA (IT) | 2011-03-09 | — | — | EP | disclosed |
| US-20100249198-A1 | (R)-4-(HETEROARYL) PHENYLETHYL DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | DOMPE S.P.A (IT) | 2010-09-30 | — | — | US | disclosed |
| EP-2201006-A1 | (R)-4-(HETEROARYL) PHENYLETHYL DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Dompé S.p.a. (IT) | 2010-06-30 | — | — | EP | disclosed |
| WO-2009050258-A1 | (R)-4-(HETEROARYL) PHENYLETHYL DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Dompé S.p.A. (IT) | 2009-04-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249198-A1 | (R)-4-(HETEROARYL) PHENYLETHYL DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | C3AR1, C5AR2, C5AR1 | TSHR 2466/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.