Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGBL2 | Q5U5Z8 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.31 |
| ▸ | NOS3 | P29474 | 1/20 | 0.31 |
| ▸ | NOS1 | P29475 | 1/20 | 0.31 |
| ▸ | NOS2 | P35228 | 1/20 | 0.31 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17000219 | 0.82 | AGBL2 (0.40) | AGBL2KDM4EUSP2HPGDHSD17B10 | |
| SCHEMBL12250728 | 0.80 | NOS3 (0.43) | AGBL2KDM4EUSP2HPGDHSD17B10 | |
| SCHEMBL21786709 | 0.79 | AGBL2 (0.38) | AGBL2KDM4EUSP2HPGDHSD17B10 | |
| SCHEMBL26199789 | 0.78 | AGBL2 (0.57) | AGBL2KDM4E | |
| SCHEMBL16386043 | 0.78 | AGBL2 (0.59) | AGBL2CXCR4NOS3NOS1NOS2 | |
| SCHEMBL27342161 | 0.77 | KDM4E (0.34) | AGBL2KDM4EUSP2HPGDHSD17B10 | |
| SCHEMBL15544538 | 0.76 | AGBL2 (0.62) | AGBL2KDM4ECXCR4NOS3NOS1 | |
| SCHEMBL16240808 | 0.76 | AGBL2 (0.58) | AGBL2CXCR4NOS3NOS1NOS2 | |
| SCHEMBL12193373 | 0.74 | AGXT (0.36) | AGBL2KDM4EUSP2HPGDHSD17B10 | |
| SCHEMBL1425018 | 0.73 | EGLN2 (0.37) | KDM4EUSP2HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023146987-A1 | COMPOUNDS AND METHODS OF USE | TANGO THERAPEUTICS, INC. (US) | 2023-08-03 | — | — | WO | disclosed |