SCHEMBL26206437

SCHEMBL26206437

C[C@@H](CCC(N)=O)COc1cc(F)cc(CCCCCC(=O)O)c1F

nearest known ligand 0.37

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ F13A1 P00488 3/20 0.37
▸ MPO P05164 2/20 0.36
▸ FOS P01100 2/20 0.35
▸ JUN P05412 2/20 0.35
▸ LTB4R Q15722 4/20 0.35
▸ LTB4R2 Q9NPC1 2/20 0.35
▸ FFAR1 O14842 2/20 0.35
▸ FFAR4 Q5NUL3 2/20 0.35
▸ CSF3R Q99062 1/20 0.33
▸ SLC6A4 P31645 1/20 0.32
▸ PRSS1 P07477 1/20 0.32
▸ TMPRSS15 P98073 1/20 0.32
▸ CYSLTR2 Q9NS75 1/20 0.32
▸ CYSLTR1 Q9Y271 1/20 0.32
▸ POLB P06746 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26206433 0.92 F13A1 (0.37) F13A1MPOFOSJUNLTB4R
SCHEMBL26206385 0.90 FOS (0.36) F13A1MPOFOSJUNLTB4R
SCHEMBL26206174 0.90 MPO (0.35) MPOSLC6A4
SCHEMBL26206394 0.90 F13A1 (0.36) F13A1MPOFOSJUNLTB4R
SCHEMBL26206383 0.87 FOS (0.36) MPOFOSJUNFFAR1FFAR4
SCHEMBL26206467 0.85 LTB4R (0.46) FOSJUNLTB4RLTB4R2CYSLTR2
SCHEMBL26206421 0.84 LTB4R (0.44) MPOFOSJUNLTB4RLTB4R2
SCHEMBL26206173 0.82 HDAC8 (0.34) MPO
SCHEMBL26206484 0.82 FFAR4 (0.37) LTB4RFFAR4CSF3R
SCHEMBL26206133 0.81 MPO (0.33) MPO

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11746120-B2 Stat degraders and uses thereof KYMERA THERAPEUTICS, INC. (US) 2023-09-05 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11746120-B2 Stat degraders and uses thereof STAT4, STAT1, STAT3 F13A1 4060/4885MPO 2309/4885FOS 3232/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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