SCHEMBL262252

SCHEMBL262252

CCCN1C(=O)c2ccc(Oc3ccc4c(c3)C(=O)N(CCC)C4=O)cc2C1=O

nearest known ligand 0.67

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.67
KDM4E B2RXH2 3/20 0.67
KMT2A Q03164 2/20 0.67
MEN1 O00255 1/20 0.67
HTT P42858 1/20 0.67
HSD17B10 Q99714 2/20 0.65
MAPK1 P28482 1/20 0.65
TDP1 Q9NUW8 2/20 0.59
LPAR3 Q9UBY5 2/20 0.56
LPAR1 Q92633 1/20 0.56
POLB P06746 2/20 0.52
HPGD P15428 2/20 0.50
NPSR1 Q6W5P4 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
BRD4 O60885 1/20 0.43
NPC1 O15118 1/20 0.43
RAB9A P51151 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12156953 0.84 KDM4E (0.51) ALDH1A1KDM4EKMT2AMEN1HTT
SCHEMBL19566733 0.84 ALDH1A1 (0.66) ALDH1A1KDM4EKMT2AMEN1HTT
SCHEMBL19499368 0.83 ALDH1A1 (0.59) ALDH1A1KDM4EKMT2AMEN1HTT
SCHEMBL18391142 0.83 KDM4E (0.82) ALDH1A1KDM4EKMT2AMEN1HTT
SCHEMBL13928043 0.82 ALDH1A1 (0.57) ALDH1A1KDM4EKMT2AMEN1HTT
SCHEMBL22681991 0.82 ALDH1A1 (0.69) ALDH1A1KDM4EKMT2AMEN1HTT
SCHEMBL22681989 0.81 KDM4E (0.79) ALDH1A1KDM4EKMT2AMEN1HTT
SCHEMBL262253 0.80 ALDH1A1 (0.57) ALDH1A1KDM4EKMT2AMEN1HTT
SCHEMBL19578688 0.79 KDM4E (0.60) ALDH1A1KDM4EKMT2AMEN1HTT
SCHEMBL15046557 0.79 CHRM2 (0.60) ALDH1A1KDM4EMAPK1HPGDNPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2097375-B1 METHOD FOR PURIFYING BISIMIDES SABIC INNOVATIVE PLASTICS IP (NL) 2013-04-24 EP disclosed
EP-2089348-B1 METHOD FOR MAKING POLYETHERIMIDES SABIC INNOVATIVE PLASTICS IP (NL) 2013-02-20 EP disclosed
US-8134016-B2 Method for purifying dianhydrides SABIC INNOVATIVE PLASTICS IP B.V. (NL) 2012-03-13 US disclosed
EP-2094691-B1 METHOD FOR PURIFYING DIANHYDRIDES SABIC INNOVATIVE PLASTICS IP (NL) 2011-05-25 EP disclosed
EP-2097375-A1 METHOD FOR PURIFYING BISIMIDES Sabic Innovative Plastics IP B.V. (NL) 2009-09-09 EP disclosed
EP-2094691-A1 METHOD FOR PURIFYING DIANHYDRIDES Sabic Innovative Plastics IP B.V. (NL) 2009-09-02 EP disclosed
EP-2089348-A1 METHOD FOR MAKING POLYETHERIMIDES Sabic Innovative Plastics IP B.V. (NL) 2009-08-19 EP disclosed
US-20080319210-A1 METHOD FOR PURIFYING DIANHYDRIDES SHPP GLOBAL TECHNOLOGIES B.V. (NL) 2008-12-25 US disclosed
US-7446214-B2 Method for purifying oxybisphthalic anhydrides SABIC INNOVATIVE PLASTICS IP B.V. (US) 2008-11-04 US disclosed
US-7411032-B2 Method for making polyetherimides SABIC INNOVATIVE PLASTICS IP B.V. (US) 2008-08-12 US disclosed
US-7408070-B2 Method for purifying bisimides SABIC INNOVATIVE PLASTICS IP B.V. (US) 2008-08-05 US disclosed
WO-2008063208-A1 METHOD FOR PURIFYING BISIMIDES SABIC INNOVATIVE PLASTICS IP B.V. (NL) 2008-05-29 WO disclosed
WO-2008063206-A1 METHOD FOR MAKING POLYETHERIMIDES SABIC INNOVATIVE PLASTICS IP B.V. (NL) 2008-05-29 WO disclosed
WO-2008063207-A1 METHOD FOR PURIFYING DIANHYDRIDES SABIC INNOVATIVE PLASTICS IP B.V. (NL) 2008-05-29 WO disclosed
US-20070073063-A1 Method for purifying bisimides GENERAL ELECTRIC COMPANY (US) 2007-03-29 US disclosed
US-20070073035-A1 Method for making polyetherimides GENERAL ELECTRIC COMPANY (US) 2007-03-29 US disclosed
US-20070073066-A1 Method for purifying dianhydrides GENERAL ELECTRIC COMPANY (US) 2007-03-29 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070073063-A1 Method for purifying bisimides FHIT, PBRM1, TNS4 ALDH1A1 4754/4885KDM4E 98/4885KMT2A 363/4885
US-20080319210-A1 METHOD FOR PURIFYING DIANHYDRIDES AQP4, TRRAP, GYPA ALDH1A1 2726/4885KDM4E 67/4885KMT2A 266/4885
US-20070073066-A1 Method for purifying dianhydrides AQP4, TRRAP, GYPA ALDH1A1 2726/4885KDM4E 67/4885KMT2A 266/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.