SCHEMBL2623

SCHEMBL2623

O=P(Cl)(Nc1ccccc1)Oc1ccccc1

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.66
HPGD P15428 3/20 0.56
LMNA P02545 3/20 0.51
MEN1 O00255 3/20 0.51
KMT2A Q03164 3/20 0.51
HTT P42858 2/20 0.51
CYP1A2 P05177 1/20 0.51
CYP2D6 P10635 1/20 0.51
CYP2C9 P11712 1/20 0.51
CYP2C19 P33261 1/20 0.51
PKM P14618 1/20 0.50
L3MBTL1 Q9Y468 2/20 0.47
SMN1; SMN2 Q16637 1/20 0.47
HCRTR1 O43613 1/20 0.47
SRC P12931 1/20 0.47
RECQL P46063 2/20 0.46
NPSR1 Q6W5P4 2/20 0.46
TDP1 Q9NUW8 1/20 0.45
CA12 O43570 1/20 0.43
CA1 P00915 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10967629 0.81 KDM4E (0.52) KDM4EHPGDLMNAMEN1KMT2A
SCHEMBL7734146 0.79 KDM4E (1.00) KDM4EHPGDLMNAMEN1KMT2A
SCHEMBL7740418 0.79 MEN1 (0.76) KDM4EHPGDLMNAMEN1KMT2A
SCHEMBL18831783 0.78 SRC (0.48) KDM4EHPGDLMNAMEN1KMT2A
SCHEMBL9115028 0.76 KDM4E (0.66) KDM4EHPGDLMNAMEN1KMT2A
SCHEMBL132235 0.75 KDM4E (0.92) KDM4EHPGDLMNAMEN1KMT2A
SCHEMBL28445426 0.74 SRC (0.46) KDM4EMEN1KMT2AHTTCYP2C9
SCHEMBL5013978 0.74 CA9 (0.48) KDM4EHPGDHTTCYP1A2CYP2D6
SCHEMBL9439409 0.73 KDM4E (0.50) KDM4EHPGDHTTCYP1A2CYP2D6
SCHEMBL28384135 0.73 KDM4E (0.50) KDM4EHPGDHTTCYP1A2CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 222 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2013112585-A1 SYNTHETIC METHODS PERTAINING TO TERT-BUTYL-BENZENE-BASED COMPOUNDS BOSTON SCIENTIFIC SCIMED, INC. (US) 2013-08-01 WO claimed
US-20130190525-A1 SYNTHETIC METHODS PERTAINING TO TERT-BUTYL-BENZENE-BASED COMPOUNDS BOSTON SCIENTIFIC SCIMED, INC. (US) 2013-07-25 US claimed
US-7834130-B2 Process for the production of polybenzimidazole from a tetraminobiphenyl and an isophthalic acid PBI PERFORMANCE PRODUCTS, INC. (US) 2010-11-16 US claimed
US-20080207869-A1 PROCESS FOR THE PRODUCTION OF POLYBENZIMIDAZOLE FROM A TETRAMINOBIPHENYL AND AN ISOPHTHALIC ACID PBI PERFORMANCE PRODUCTS, INC. 2008-08-28 US claimed
CN-119742007-A Method for screening DES (DES) by utilizing ANN and COSMO-RS and extracting oil tea polysaccharide based on DES combined with double-enzyme method 四川农业大学 2025-04-01 CN disclosed
US-12107264-B2 Anode active material comprising metal phosphide coating on surface of carbon material, preparation method therefor, nonaqueous lithium secondary battery comprising anode active material, and manufacturing method therefor KOREA ELECTROTECHNOLOGY RESEARCH INSTITUTE (KR) 2024-10-01 US disclosed
WO-2024075736-A1 NITROGEN-CONTAINING COMPOUND, COMPOSITION COMPRISING SAID NITROGEN-CONTAINING COMPOUND, AND MARKER FOR PREDICTING TUMOR GRADE 学校法人関西医科大学 2024-04-11 WO disclosed
US-20220216462-A1 ANODE ACTIVE MATERIAL COMPRISING METAL PHOSPHIDE COATING ON SURFACE OF CARBON MATERIAL, PREPARATION METHOD THEREFOR, NONAQUEOUS LITHIUM SECONDARY BATTERY COMPRISING ANODE ACTIVE MATERIAL, AND MANUFACTURING METHOD THEREFOR KOREA ELECTROTECHNOLOGY RESEARCH INSTITUTE (KR) 2022-07-07 US disclosed
CN-114675458-A High-performance hydrogen bond organic framework material electrochromic device 辽宁大学 2022-06-28 CN disclosed
WO-2013112585-A1 SYNTHETIC METHODS PERTAINING TO TERT-BUTYL-BENZENE-BASED COMPOUNDS BOSTON SCIENTIFIC SCIMED, INC. (US) 2013-08-01 WO disclosed
US-20130190525-A1 SYNTHETIC METHODS PERTAINING TO TERT-BUTYL-BENZENE-BASED COMPOUNDS BOSTON SCIENTIFIC SCIMED, INC. (US) 2013-07-25 US disclosed
US-7834130-B2 Process for the production of polybenzimidazole from a tetraminobiphenyl and an isophthalic acid PBI PERFORMANCE PRODUCTS, INC. (US) 2010-11-16 US disclosed
EP-0144290-A2 Substituted ethylenediamine derivatives CIBA-GEIGY AG (CH) 1985-06-12 EP disclosed
EP-0143746-A2 5-Amino 4-hydroxy-valeryl-substituted derivatives CIBA-GEIGY AG (CH) 1985-06-05 EP disclosed
US-4483977-A TETRAMINOBIPHENYL AND ISOPHTHALIC ACID CELANESE CORPORATION (US) 1984-11-20 US disclosed
EP-0111266-A2 Substituted tetrapeptides CIBA-GEIGY AG (CH) 1984-06-20 EP disclosed
US-4452967-A MELT POLYMERIZATION OF AROMATIC CARBOXY DIAMINE CELANESE CORPORATION (US) 1984-06-05 US disclosed
EP-0095348-A2 High molecular weight polybenzimidazoles CELANESE CORPORATION (US) 1983-11-30 EP disclosed
US-4414383-A High molecular weight polybenzimidazole preparation with phosphorus containing polymerization catalyst CELANESE CORPORATION (US) 1983-11-08 US disclosed
EP-0091130-A2 Cephalosporin derivatives, process for preparing and pharmaceutical compositions containing said compounds DAIICHI SEIYAKU CO., LTD. (JP) 1983-10-12 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130190525-A1 SYNTHETIC METHODS PERTAINING TO TERT-BUTYL-BENZENE-BASED COMPOUNDS TERT, HMBS, BET1 KDM4E 467/4885HPGD 1887/4885LMNA 2560/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.