Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 3/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.44 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 9/20 | 0.43 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 5/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 5/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 5/20 | 0.38 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.38 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.38 |
| ▸ | GCGR | P47871 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | RAF1 | P04049 | 1/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26242506 | 0.83 | CNR1 (0.45) | CACNA2D1 | |
| SCHEMBL15038352 | 0.80 | ADORA2A (0.49) | ADORA2AADORA1ADORA2BMAPK14RAB9A | |
| SCHEMBL26242510 | 0.79 | SMO (0.34) | ADORA2AADORA1 | |
| SCHEMBL26242537 | 0.78 | MAPT (0.43) | MAPK14MAPK13MAPK12MAPK11CSNK1D | |
| SCHEMBL26242505 | 0.78 | MAOB (0.44) | ADORA2AADORA1ADORA2BMAPK14NPC1 | |
| SCHEMBL26242509 | 0.77 | ADORA2A (0.50) | ADORA2AADORA1ADORA2BMAPK14MAPK13 | |
| SCHEMBL26246652 | 0.76 | KMT2A (0.54) | ADORA1CACNA2D1NPC1RAB9APTGS2 | |
| SCHEMBL30617006 | 0.75 | MAPK14 (0.41) | ADORA2AADORA1ADORA2BMAPK14NPC1 | |
| SCHEMBL1262220 | 0.74 | KMT2A (0.33) | NPC1RAB9A | |
| SCHEMBL26242514 | 0.73 | SLC34A1 (0.36) | MAPK14CACNA2D1CSNK1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023150201-A2 | SODIUM CHANNEL BLOCKING COMPOUNDS, DERIVATIVES THEREOF, AND METHODS OF THEIR USE | LATIGO BIOTHERAPEUTICS, INC. (US) | 2023-08-10 | — | — | WO | disclosed |