SCHEMBL26243787

SCHEMBL26243787

C=CC(=O)Nc1c(N2CCN(C)CC2)ccc(F)c1C

nearest known ligand 0.44

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
WDR5 P61964 14/20 0.44
KDM4E B2RXH2 1/20 0.44
EGFR P00533 1/20 0.44
UCHL3 P15374 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.43
GAA P10253 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29410354 0.75 TGM2 (0.46)
SCHEMBL25247069 0.75 TGM2 (0.46)
SCHEMBL27361372 0.74 UCHL3 (0.51) WDR5EGFRUCHL3SMN1; SMN2GAA
SCHEMBL16634492 0.74 TGM2 (0.42)
SCHEMBL25394386 0.73 SMN1; SMN2 (0.42) WDR5KDM4ESMN1; SMN2GAA
SCHEMBL30599328 0.73 SMN1; SMN2 (0.42) WDR5KDM4ESMN1; SMN2GAA
SCHEMBL30599296 0.73 SMN1; SMN2 (0.48) WDR5SMN1; SMN2GAA
SCHEMBL25395848 0.73 SMN1; SMN2 (0.42) WDR5KDM4ESMN1; SMN2GAA
SCHEMBL25397477 0.73 SMN1; SMN2 (0.48) WDR5SMN1; SMN2GAA
SCHEMBL30599307 0.73 SMN1; SMN2 (0.48) WDR5SMN1; SMN2GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023166303-A1 ACRYLAMIDE COMPOUNDS NRG THERAPEUTICS LTD (GB) 2023-09-07 WO disclosed