⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18513359 | 0.83 | NOD1 (0.34) | — | |
| SCHEMBL21029776 | 0.74 | — | — | |
| SCHEMBL20643464 | 0.69 | NOD1 (0.36) | — | |
| SCHEMBL20756564 | 0.68 | NOD1 (0.36) | — | |
| SCHEMBL21216105 | 0.68 | ACE (0.38) | — | |
| SCHEMBL16248526 | 0.67 | NOD1 (0.36) | — | |
| SCHEMBL16248525 | 0.67 | NOD1 (0.36) | — | |
| SCHEMBL21029641 | 0.66 | — | — | |
| SCHEMBL18513225 | 0.66 | NOD1 (0.38) | — | |
| SCHEMBL25772845 | 0.66 | NOD1 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230357776-A1 | COMPOSITIONS AND METHODS FOR MODULATING COMPLEMENT FACTOR B EXPRESSION | IONIS PHARMACEUTICALS, INC. (US) | 2023-11-09 | — | — | US | disclosed |
| US-11732265-B2 | Compositions and methods for modulating complement factor B expression | IONIS PHARMACEUTICALS, INC. (US) | 2023-08-22 | — | — | US | disclosed |