Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.43 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.43 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.43 |
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.43 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 5/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 5/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | CHKA | P35790 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9835086 | 0.98 | CHRM2 (0.44) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| Bromide SCHEMBL9330832 | 0.97 | CHRM2 (0.46) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| Hydrochloric Acid SCHEMBL9330040 | 0.94 | MEN1 (0.40) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL9834006 | 0.92 | MEN1 (0.41) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| Bromide SCHEMBL9330798 | 0.90 | CHRM2 (0.41) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL7063921 | 0.80 | CHRM2 (0.55) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| Hydrochloric Acid SCHEMBL5143850 | 0.74 | CHKA (0.53) | MAPTHTTCHKANPC1LMNA | |
| SCHEMBL7153351 | 0.73 | EGFR (0.50) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL34468104 | 0.72 | CHKA (0.55) | HTTCHKANPC1LMNARAB9A | |
| Hydrochloric Acid SCHEMBL6687261 | 0.72 | CHRM2 (0.40) | CHRM2CHRM4CHRM5CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060205958-A1 | Direct dianhydride synthesis | GENERAL ELECTRIC COMPANY | 2006-09-14 | — | — | US | claimed |
| EP-0252964-B1 | CATALYTIC METHOD FOR PRODUCING FLUOROAROMATIC COMPOUNDS USING SUBSTITUTED PYRIDINIUM SALTS | MALLINCKRODT SPECIALTY CHEMICALS COMPANY (US) | 1991-08-21 | — | — | EP | claimed |
| US-4973772-A | Catalytic method for producing fluoroarmatic compounds using substituted pyridinium salts | MALLINCKRODT, INC. (US) | 1990-11-27 | — | — | US | claimed |
| EP-2280963-B1 | METHOD OF PURIFYING DIANHYDRIDES, THE DIANHYDRIDES FORMED THEREBY, AND POLYETHERIMIDES FORMED THEREFROM | SABIC GLOBAL TECHNOLOGIES BV (NL) | 2016-07-20 | — | — | EP | disclosed |
| EP-2097375-B1 | METHOD FOR PURIFYING BISIMIDES | SABIC INNOVATIVE PLASTICS IP (NL) | 2013-04-24 | — | — | EP | disclosed |
| EP-2089348-B1 | METHOD FOR MAKING POLYETHERIMIDES | SABIC INNOVATIVE PLASTICS IP (NL) | 2013-02-20 | — | — | EP | disclosed |
| US-8134016-B2 | Method for purifying dianhydrides | SABIC INNOVATIVE PLASTICS IP B.V. (NL) | 2012-03-13 | — | — | US | disclosed |
| US-8013173-B2 | Method of purifying dianhydrides, the dianhydrides formed thereby, and polyetherimides formed therefrom | SABIC INNOVATIVE PLASTICS IP B.V. (NL) | 2011-09-06 | — | — | US | disclosed |
| EP-2094691-B1 | METHOD FOR PURIFYING DIANHYDRIDES | SABIC INNOVATIVE PLASTICS IP (NL) | 2011-05-25 | — | — | EP | disclosed |
| EP-2280963-A1 | METHOD OF PURIFYING DIANHYDRIDES, THE DIANHYDRIDES FORMED THEREBY, AND POLYETHERIMIDES FORMED THEREFROM | SABIC Innovative Plastics IP B.V. (NL) | 2011-02-09 | — | — | EP | disclosed |
| US-20090247727-A1 | Method of Purifying Dianhydrides, the Dianhydrides Formed Thereby, and Polyetherimides Formed Therefrom | SHPP GLOBAL TECHNOLOGIES B.V. (NL) | 2009-10-01 | — | — | US | disclosed |
| US-4916253-A | Fluorobenzoates and process for their production | IHARA CHEMICAL INDUSTRY COMPANY, LTD. (JP) | 1990-04-10 | — | — | US | disclosed |
| EP-0321296-A1 | Lipid derivatives their preparation and use | SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD. (JP) | 1989-06-21 | — | — | EP | disclosed |
| EP-0296479-A2 | Fluorobenzoates and process for their production | IHARA CHEMICAL INDUSTRY Co., Ltd. (JP) | 1988-12-28 | — | — | EP | disclosed |
| EP-0252964-A4 | CATALYTIC METHOD FOR PRODUCING FLUOROAROMATIC COMPOUNDS USING SUBSTITUTED PYRIDINIUM SALTS. | MALLINCKRODT INC (US) | 1988-07-14 | — | — | EP | disclosed |
| EP-0252964-A1 | CATALYTIC METHOD FOR PRODUCING FLUOROAROMATIC COMPOUNDS USING SUBSTITUTED PYRIDINIUM SALTS. | MALLINCKRODT INC (US) | 1988-01-20 | — | — | EP | disclosed |
| WO-1987004150-A1 | CATALYTIC METHOD FOR PRODUCING FLUOROAROMATIC COMPOUNDS USING SUBSTITUTED PYRIDINIUM SALTS | MALLINCKRODT, INC. (US) | 1987-07-16 | — | — | WO | disclosed |
| US-4605745-A | PHASE TRANSFER CATALYSTS; AROMATIC ETHERS IN IMPROVED YIELDS | GENERAL ELECTRIC COMPANY (US) | 1986-08-12 | — | — | US | disclosed |
| US-4513141-A | BY DISPLACING REACTIVE RADICALS ON AROMATIC NUCLEUS | GENERAL ELECTRIC COMPANY (US) | 1985-04-23 | — | — | US | disclosed |
| EP-0126950-A2 | Method for making aromatic ethers and catalyst used in such method | GENERAL ELECTRIC COMPANY (US) | 1984-12-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060205958-A1 | Direct dianhydride synthesis | HDHD5, DOHH, DBH | CHRM2 4458/4885CHRM1 4363/4885CHRM3 4537/4885 |
| US-20090247727-A1 | Method of Purifying Dianhydrides, the Dianhydrides Formed Thereby, and Polyetherimides Formed Therefrom | CA7, CA4, CA13 | CHRM2 3933/4885CHRM1 4443/4885CHRM3 4306/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.