Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2801701 | 0.84 | POLB (0.30) | — | |
| SCHEMBL12452318 | 0.73 | ALDH1A1 (0.44) | NFKB1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL12051510 | 0.73 | SORD (0.31) | — | |
| SCHEMBL32909 | 0.73 | — | — | |
| SCHEMBL21153211 | 0.71 | — | — | |
| SCHEMBL21400714 | 0.71 | ADORA2A (0.37) | — | |
| SCHEMBL5131454 | 0.71 | ALDH1A1 (0.50) | NFKB1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL28330607 | 0.70 | ALDH1A1 (0.57) | NFKB1 | |
| SCHEMBL965404 | 0.70 | — | — | |
| SCHEMBL19367730 | 0.68 | CYP1A2 (0.36) | CYP1A2CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8163763-B2 | Pyrimidine compounds, compositions and methods of use | GENENTECH, INC. (US) | 2012-04-24 | — | — | US | disclosed |
| US-8163763-B2 | Pyrimidine compounds, compositions and methods of use | GENENTECH, INC. (US) | 2012-04-24 | — | — | US | disclosed |