Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Benzthiazide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 3/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 3/20 | 1.00 |
| ▸ | TSHR | P16473 | 2/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 1.00 |
| ▸ | MEN1 | O00255 | 1/20 | 1.00 |
| ▸ | NR1I2 | O75469 | 1/20 | 1.00 |
| ▸ | ABCB11 | O95342 | 1/20 | 1.00 |
| ▸ | ADRA2A | P08913 | 1/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 1/20 | 1.00 |
| ▸ | PKM | P14618 | 1/20 | 1.00 |
| ▸ | ADRA2B | P18089 | 1/20 | 1.00 |
| ▸ | ADRA2C | P18825 | 1/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 1/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 9/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzthiazide SCHEMBL29495263 | 1.00 | ALDH1A1 (1.00) | ALDH1A1CYP3A4CYP2C9TSHRSMN1; SMN2 | |
| Benzthiazide SCHEMBL26257 | 0.77 | ALDH1A1 (0.63) | ALDH1A1CYP3A4CYP2C9TSHRSMN1; SMN2 | |
| Benzthiazide SCHEMBL6546528 | 0.76 | ALDH1A1 (0.62) | ALDH1A1CYP3A4CYP2C9TSHRSMN1; SMN2 | |
| Benzthiazide SCHEMBL7102453 | 0.76 | ALDH1A1 (0.62) | ALDH1A1CYP3A4CYP2C9TSHRSMN1; SMN2 | |
| Benzthiazide SCHEMBL345215 | 0.76 | ALDH1A1 (0.62) | ALDH1A1CYP3A4CYP2C9TSHRSMN1; SMN2 | |
| Benzthiazide SCHEMBL9517821 | 0.76 | ALDH1A1 (0.62) | ALDH1A1CYP3A4CYP2C9TSHRSMN1; SMN2 | |
| Benzthiazide SCHEMBL7217920 | 0.76 | ALDH1A1 (0.62) | ALDH1A1CYP3A4CYP2C9TSHRSMN1; SMN2 | |
| SCHEMBL3863724 | 0.76 | ALDH1A1 (0.61) | ALDH1A1CYP3A4CYP2C9TSHRSMN1; SMN2 | |
| Benzthiazide SCHEMBL1276519 | 0.75 | ALDH1A1 (0.60) | ALDH1A1CYP3A4CYP2C9TSHRSMN1; SMN2 | |
| SCHEMBL3864106 | 0.74 | ALDH1A1 (0.59) | ALDH1A1CYP3A4CYP2C9TSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 9643 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2026090360-A1 | FUSED PYRIMIDINE COMPOUNDS FOR TREATMENT OF TINNITUS, HEARING LOSS, AND MENIERE'S DISEASE | OVID THERAPEUTICS INC. (US) | 2026-04-30 | — | — | WO | claimed |
| US-20260108529-A1 | FUSED AMINO PYRIMIDINE COMPOUNDS FOR TREATMENT OF TINNITUS, ACUTE SENSORINEURAL HEARING LOSS, AGE-RELATED HEARING LOSS, AND MENIERE'S DISEASE | OVID THERAPEUTICS INC (US) | 2026-04-23 | — | — | US | claimed |
| EP-4722714-A1 | SIMULTANEOUS ANALYSIS OF FOOD-BORNE DOPING SUBSTANCES USING LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY (VFD: VACCINE FOR FOODBORNE DOPING) | Korea Institute of Science and Technology (KR) | 2026-04-08 | — | — | EP | claimed |
| WO-2025111482-A1 | COMPLEXING AGENT SALT FORMULATIONS OF PHARMACEUTICAL COMPOUNDS AT LOW STOICHIOMETRIC RATIOS | BEXSON BIOMEDICAL, INC. (US) | 2025-05-30 | — | — | WO | claimed |
| WO-2024028324-A1 | MOLECULES FOR THE PREVENTION AND TREATMENT OF NEUROMUSCULAR DISORDERS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (FR) | 2024-02-08 | — | — | WO | claimed |
| US-20240002935-A1 | GENETIC METHOD FOR DIAGNOSIS AND TREATMENT OF PRE AND POST CORONAVIRUS INFECTIONS | GENETICURE INC. | 2024-01-04 | — | — | US | claimed |
| US-20230266330-A1 | EXOSOMAL TUMOR BIOMARKERS AND COLLECTIONS THEREOF | CORNELL UNIVERSITY | 2023-08-24 | — | — | US | claimed |
| CN-115787323-A | Low ammonia nitrogen printing process | 华纺股份有限公司 | 2023-03-14 | — | — | CN | claimed |
| EP-4132653-A1 | GENETIC METHOD FOR DIAGNOSIS AND TREATMENT OF PRE AND POST CORONAVIRUS INFECTIONS | Geneticure Inc. (US) | 2023-02-15 | — | — | EP | claimed |
| CN-115400697-A | Automatic control method and system for double-layer structure carbon-three-liquid phase hydrogenation reactor and hydrogenation reactor | 中国石油化工股份有限公司 | 2022-11-29 | — | — | CN | claimed |
| EP-0000561-B1 | WATER-SOLUBLE, RETICULATED NITROGENOUS CONDENSATION PRODUCTS AND THEIR USE | BASF Aktiengesellschaft (DE) | 1981-10-14 | — | — | EP | claimed |
| US-4285947-A | DIURETICS, HYPOTENSIVES | INTERX RESEARCH CORPORATION (US) | 1981-08-25 | — | — | US | claimed |
| EP-0032725-A1 | Novel aldehyde adducts of triamterene and a pharmaceutical composition containing the same | MERCK & CO. INC. (US) | 1981-07-29 | — | — | EP | claimed |
| US-4238485-A | 1,2,5-THIADIAZOLE DERIVATIVE, THIAZIDE DIURETIC, HYPOTENSIVE AGENTS | MERCK & CO., INC. (US) | 1980-12-09 | — | — | US | claimed |
| US-4217347-A | MERCAPTOALKYL ALKANOYLPROLINES AND A DIURETIC | E. R. SQUIBB & SONS, INC. (US) | 1980-08-12 | — | — | US | claimed |
| EP-0007097-A1 | Tensio-active polypodes, process for their preparation and compositions containing them | L'OREAL (FR) | 1980-01-23 | — | — | EP | claimed |
| US-4178374-A | SUBSTITUTED 1,2,5-THIADIAZOLE B-ADRENERGIC BLOCKING AGENT, PYRAZINE AND/OR THIAZIDE DIURETIC, TREATMENT OF HYPERTENSION | MERCK & CO., INC. (US) | 1979-12-11 | — | — | US | claimed |
| EP-0004863-A1 | Cosmetic and pharmaceutical compositions, tensioactive cyclic polyethers and methods for preparing them | L'OREAL (FR) | 1979-10-31 | — | — | EP | claimed |
| US-4022894-A | Stable solution of benzthiazide (3-[benzythiol methyl]-6-chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide) suitable for parenteral administration and process of preparation | FAINBERG SAMUEL M | 1977-05-10 | — | — | US | claimed |
| US-3963674-A | Process for the production of halogenated carboxylic acid amides | CHEMISCHE FABRIK KALK GMBH (DT) | 1976-06-15 | — | — | US | claimed |