Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Benzthiazide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 3/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 3/20 | 1.00 |
| ▸ | TSHR | P16473 | 2/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 1.00 |
| ▸ | MEN1 | O00255 | 1/20 | 1.00 |
| ▸ | NR1I2 | O75469 | 1/20 | 1.00 |
| ▸ | ABCB11 | O95342 | 1/20 | 1.00 |
| ▸ | ADRA2A | P08913 | 1/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 1/20 | 1.00 |
| ▸ | PKM | P14618 | 1/20 | 1.00 |
| ▸ | ADRA2B | P18089 | 1/20 | 1.00 |
| ▸ | ADRA2C | P18825 | 1/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 1/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 9/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzthiazide SCHEMBL26258 | 1.00 | ALDH1A1 (1.00) | ALDH1A1CYP3A4CYP2C9TSHRSMN1; SMN2 | |
| Benzthiazide SCHEMBL26257 | 0.77 | ALDH1A1 (0.63) | ALDH1A1CYP3A4CYP2C9TSHRSMN1; SMN2 | |
| Benzthiazide SCHEMBL6546528 | 0.76 | ALDH1A1 (0.62) | ALDH1A1CYP3A4CYP2C9TSHRSMN1; SMN2 | |
| Benzthiazide SCHEMBL7102453 | 0.76 | ALDH1A1 (0.62) | ALDH1A1CYP3A4CYP2C9TSHRSMN1; SMN2 | |
| Benzthiazide SCHEMBL345215 | 0.76 | ALDH1A1 (0.62) | ALDH1A1CYP3A4CYP2C9TSHRSMN1; SMN2 | |
| Benzthiazide SCHEMBL9517821 | 0.76 | ALDH1A1 (0.62) | ALDH1A1CYP3A4CYP2C9TSHRSMN1; SMN2 | |
| Benzthiazide SCHEMBL7217920 | 0.76 | ALDH1A1 (0.62) | ALDH1A1CYP3A4CYP2C9TSHRSMN1; SMN2 | |
| SCHEMBL3863724 | 0.76 | ALDH1A1 (0.61) | ALDH1A1CYP3A4CYP2C9TSHRSMN1; SMN2 | |
| Benzthiazide SCHEMBL1276519 | 0.75 | ALDH1A1 (0.60) | ALDH1A1CYP3A4CYP2C9TSHRSMN1; SMN2 | |
| SCHEMBL3864106 | 0.74 | ALDH1A1 (0.59) | ALDH1A1CYP3A4CYP2C9TSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4295254-B1 | METHOD FOR MONITORING CONTAINER APPLICATIONS ON A HOST SYSTEM AND INSTALLATION | SIEMENS AG (DE) | 2026-04-29 | — | — | EP | disclosed |
| US-12602489-B2 | Vulnerability applicability assessment and determination | INTERNATIONAL BUSINESS MACHINES CORPORATION (US) | 2026-04-14 | — | — | US | disclosed |
| US-20250265350-A1 | Vulnerability Applicability Assessment and Determination | INTERNATIONAL BUSINESS MACHINES CORPORATION | 2025-08-21 | — | — | US | disclosed |
| EP-4584707-A1 | METHOD AND SYSTEM FOR ENVIRONMENT-DEPENDENT SECURITY-RELATED ANOMALY DETECTION FOR A CONTAINER INSTANCE | Siemens Aktiengesellschaft (DE) | 2025-07-16 | — | — | EP | disclosed |
| US-12277446-B2 | Runtime container protection | CISCO TECHNOLOGY, INC. (US) | 2025-04-15 | — | — | US | disclosed |
| US-12229250-B2 | System and method for automated security tool integration | ACCENTURE GLOBAL SOLUTIONS LIMITED (IE) | 2025-02-18 | — | — | US | disclosed |
| CN-119088509-B | Docker mirror image management method, device, equipment and medium of product storage system | 广州嘉为科技有限公司 | 2025-02-11 | — | — | CN | disclosed |
| US-20250017343-A1 | Hair Beauty Instrument | YA-MAN LTD. (JP) | 2025-01-16 | — | — | US | disclosed |
| CN-119302502-A | Hair beauty device | 雅萌股份有限公司 | 2025-01-14 | — | — | CN | disclosed |
| CN-119088509-A | Docker mirror image management method, device, equipment and medium of product storage system | 广州嘉为科技有限公司 | 2024-12-06 | — | — | CN | disclosed |
| CN-117413264-A | Method and apparatus for monitoring a container application on a host system in view of manipulation | 西门子股份公司 | 2024-01-16 | — | — | CN | disclosed |
| EP-4295254-A1 | METHOD FOR CHECKING CONTAINER APPLICATIONS ON A HOST SYSTEM FOR MANIPULATION, AND SYSTEM | Siemens Aktiengesellschaft (DE) | 2023-12-27 | — | — | EP | disclosed |
| CN-116318793-A | Cloud security detection method, device and storage medium | 北京瀚马信息科技有限公司 | 2023-06-23 | — | — | CN | disclosed |
| US-11650487-B2 | Front converter optical assembly for camera | REILEY DANIEL JOSEPH (US) | 2023-05-16 | — | — | US | disclosed |
| US-20230112966-A1 | METHOD AND SYSTEM FOR GENERATING SECURITY FINDINGS ACQUISITION RECORDS FOR SYSTEMS AND SYSTEM COMPONENTS | DELL PRODUCTS L.P. | 2023-04-13 | — | — | US | disclosed |
| EP-4127994-A1 | METHOD AND DEVICE FOR SECURELY STARTING UP A CONTAINER INSTANCE | Siemens Aktiengesellschaft (DE) | 2023-02-08 | — | — | EP | disclosed |
| WO-2022207347-A1 | METHOD FOR CHECKING CONTAINER APPLICATIONS ON A HOST SYSTEM FOR MANIPULATION, AND SYSTEM | SIEMENS AKTIENGESELLSCHAFT (DE) | 2022-10-06 | — | — | WO | disclosed |
| EP-4068126-A1 | METHOD FOR MONITORING CONTAINER APPLICATIONS ON A HOST SYSTEM AND INSTALLATION | Siemens Aktiengesellschaft (DE) | 2022-10-05 | — | — | EP | disclosed |
| US-20220300330-A1 | Runtime Container Protection | CISCO TECHNOLOGY, INC. | 2022-09-22 | — | — | US | disclosed |
| EP-3969122-A1 | METHODS OF CHARACTERIZING AND UTILIZING AGENT-CONDENSATE INTERACTIONS | Whitehead Institute For Biomedical Research (US) | 2022-03-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12602489-B2 | Vulnerability applicability assessment and determination | SET, SENP8, SNW1 | ALDH1A1 4526/4885CYP3A4 3657/4885CYP2C9 3550/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.