SCHEMBL262653

SCHEMBL262653

CCCC(F)C(F)(F)C(F)(F)C=C(C)C(=O)O

nearest known ligand 0.31

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
CHRM1 P11229 1/20 0.31
AKR1A1 P14550 1/20 0.31
CHRM3 P20309 1/20 0.31
HTR2A P28223 1/20 0.31
HTR2C P28335 1/20 0.31
ADRA1A P35348 1/20 0.31
HRH1 P35367 1/20 0.31
DRD3 P35462 1/20 0.31
SLC6A3 Q01959 1/20 0.31
HDAC1 Q13547 1/20 0.31
HDAC2 Q92769 1/20 0.31
TDP1 Q9NUW8 1/20 0.31
MAPT P10636 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL532589 0.81
SCHEMBL4866043 0.78
SCHEMBL225151 0.78
SCHEMBL3417523 0.77
SCHEMBL3417525 0.77
SCHEMBL2804458 0.76
SCHEMBL14861338 0.75
SCHEMBL7029256 0.72
SCHEMBL9446214 0.72 KDM4E (0.33) TDP1
SCHEMBL8165230 0.72

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2443486-B1 BIOMEDICAL DEVICES BAUSCH & LOMB (US) 2017-03-01 EP claimed
US-8133960-B2 Biomedical devices BAUSCH & LOMB INCORPORATED (US) 2012-03-13 US claimed
US-8133960-B2 Biomedical devices BAUSCH & LOMB INCORPORATED (US) 2012-03-13 US disclosed
US-8083348-B2 Biomedical devices BAUSCH & LOMB INCORPORATED (US) 2011-12-27 US disclosed
US-20100317816-A1 Biomedical devices BAUSCH & LOMB INCORPORATED (US) 2010-12-16 US disclosed
US-7829254-B2 Non-magnetic toner, image forming apparatus and process cartridge RICOH COMPANY, LTD. (JP) 2010-11-09 US disclosed
US-20100149482-A1 CONTACT LENS BAUSCH & LOMB INCORPORATED 2010-06-17 US disclosed
US-20090173643-A1 Packaging Solutions LAI YU-CHIN 2009-07-09 US disclosed
US-20090156708-A1 BIOMEDICAL DEVICES SOLTA MEDICAL IRELAND LIMITED (IE) 2009-06-18 US disclosed
US-20070218388-A1 NON-MAGNETIC TONER, IMAGE FORMING APPARATUS AND PROCESS CARTRIDGE RICOH COMPANY, LTD. (JP) 2007-09-20 US disclosed