Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 13/20 | 0.64 |
| ▸ | DDB1 | Q16531 | 12/20 | 0.64 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.57 |
| ▸ | MGLL | Q99685 | 1/20 | 0.49 |
| ▸ | KIF11 | P52732 | 1/20 | 0.43 |
| ▸ | TNKS | O95271 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31731890 | 0.85 | CRBN (0.64) | CRBNDDB1ALOX5TNKS | |
| SCHEMBL31731817 | 0.85 | CRBN (0.64) | CRBNDDB1ALOX5TNKS | |
| SCHEMBL31105686 | 0.85 | CRBN (0.64) | CRBNDDB1ALOX5TNKS | |
| SCHEMBL10338954 | 0.85 | ALOX5 (0.52) | CRBNDDB1ALOX5MGLLKIF11 | |
| SCHEMBL26502724 | 0.85 | CRBN (0.59) | CRBNDDB1ALOX5TNKS | |
| SCHEMBL25942786 | 0.81 | CRBN (0.65) | CRBNDDB1MGLL | |
| SCHEMBL30830683 | 0.81 | CRBN (0.58) | CRBNDDB1 | |
| SCHEMBL22941454 | 0.80 | CRBN (0.69) | CRBNDDB1ALOX5MGLL | |
| SCHEMBL20577484 | 0.78 | CRBN (0.45) | CRBNDDB1ALOX5 | |
| SCHEMBL30483680 | 0.78 | CRBN (0.45) | CRBNDDB1ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4328219-A1 | SOS1 DEGRADING AGENT AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | Shanghai Leadingtac Pharmaceutical Co. Ltd. (CN) | 2024-02-28 | — | — | EP | disclosed |
| WO-2023178130-A1 | SOS1 PROTEIN DEGRADERS, PHARMACEUTICAL COMPOSITIONS, AND THERAPEUTIC APPLICATIONS | BIOTHERYX, INC. (US) | 2023-09-21 | — | — | WO | disclosed |