SCHEMBL262671

SCHEMBL262671

CCCCN1C(=O)c2cccc(Oc3cccc4c3C(=O)N(CCCC)C4=O)c2C1=O

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 4/20 0.47
KMT2A Q03164 4/20 0.47
ATM Q13315 3/20 0.47
TDP1 Q9NUW8 2/20 0.47
MAPT P10636 2/20 0.47
POLB P06746 2/20 0.47
RGS12 O14924 1/20 0.47
USP2 O75604 1/20 0.47
MAPK1 P28482 1/20 0.47
HTT P42858 1/20 0.47
NPSR1 Q6W5P4 1/20 0.47
TLR9 Q9NR96 1/20 0.47
L3MBTL1 Q9Y468 1/20 0.47
SMN1; SMN2 Q16637 1/20 0.46
NPC1 O15118 4/20 0.44
RAB9A P51151 4/20 0.44
KDM4E B2RXH2 1/20 0.44
PABPC1 P11940 1/20 0.44
ALDH1A1 P00352 1/20 0.43
ALDH2 P05091 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8483477 0.86 SMN1; SMN2 (0.49) MEN1KMT2AATMTDP1MAPT
SCHEMBL14560520 0.81 MAPT (0.63) MEN1KMT2AATMTDP1MAPT
SCHEMBL3015624 0.80 DRD2 (0.48) MEN1KMT2AATMTDP1MAPT
SCHEMBL2888769 0.80 MEN1 (0.51) MEN1KMT2AATMTDP1MAPT
SCHEMBL14560522 0.80 ANPEP (0.52) MEN1KMT2AATMTDP1MAPT
SCHEMBL9815131 0.79 MEN1 (0.47) MEN1KMT2AATMTDP1MAPT
SCHEMBL8482955 0.79 TDP1 (0.41) KMT2AATMTDP1MAPTPOLB
SCHEMBL29511230 0.78 CHRM2 (0.61) MEN1KMT2ATDP1L3MBTL1ALDH1A1
SCHEMBL149620 0.78 CHRM2 (0.61) MEN1KMT2ATDP1L3MBTL1ALDH1A1
SCHEMBL9425173 0.77 ALDH1A1 (0.51) MEN1KMT2AMAPTHTTSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2097375-B1 METHOD FOR PURIFYING BISIMIDES SABIC INNOVATIVE PLASTICS IP (NL) 2013-04-24 EP disclosed
EP-2089348-B1 METHOD FOR MAKING POLYETHERIMIDES SABIC INNOVATIVE PLASTICS IP (NL) 2013-02-20 EP disclosed
US-8134016-B2 Method for purifying dianhydrides SABIC INNOVATIVE PLASTICS IP B.V. (NL) 2012-03-13 US disclosed
EP-2094691-B1 METHOD FOR PURIFYING DIANHYDRIDES SABIC INNOVATIVE PLASTICS IP (NL) 2011-05-25 EP disclosed
EP-2097375-A1 METHOD FOR PURIFYING BISIMIDES Sabic Innovative Plastics IP B.V. (NL) 2009-09-09 EP disclosed
EP-2094691-A1 METHOD FOR PURIFYING DIANHYDRIDES Sabic Innovative Plastics IP B.V. (NL) 2009-09-02 EP disclosed
EP-2089348-A1 METHOD FOR MAKING POLYETHERIMIDES Sabic Innovative Plastics IP B.V. (NL) 2009-08-19 EP disclosed
US-20080319210-A1 METHOD FOR PURIFYING DIANHYDRIDES SHPP GLOBAL TECHNOLOGIES B.V. (NL) 2008-12-25 US disclosed
US-7446214-B2 Method for purifying oxybisphthalic anhydrides SABIC INNOVATIVE PLASTICS IP B.V. (US) 2008-11-04 US disclosed
US-7411032-B2 Method for making polyetherimides SABIC INNOVATIVE PLASTICS IP B.V. (US) 2008-08-12 US disclosed
US-7408070-B2 Method for purifying bisimides SABIC INNOVATIVE PLASTICS IP B.V. (US) 2008-08-05 US disclosed
WO-2008063208-A1 METHOD FOR PURIFYING BISIMIDES SABIC INNOVATIVE PLASTICS IP B.V. (NL) 2008-05-29 WO disclosed
WO-2008063206-A1 METHOD FOR MAKING POLYETHERIMIDES SABIC INNOVATIVE PLASTICS IP B.V. (NL) 2008-05-29 WO disclosed
WO-2008063207-A1 METHOD FOR PURIFYING DIANHYDRIDES SABIC INNOVATIVE PLASTICS IP B.V. (NL) 2008-05-29 WO disclosed
US-20070073035-A1 Method for making polyetherimides GENERAL ELECTRIC COMPANY (US) 2007-03-29 US disclosed
US-20070073063-A1 Method for purifying bisimides GENERAL ELECTRIC COMPANY (US) 2007-03-29 US disclosed
US-20070073066-A1 Method for purifying dianhydrides GENERAL ELECTRIC COMPANY (US) 2007-03-29 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070073063-A1 Method for purifying bisimides FHIT, PBRM1, TNS4 MEN1 1143/4885KMT2A 363/4885ATM 3682/4885
US-20080319210-A1 METHOD FOR PURIFYING DIANHYDRIDES AQP4, TRRAP, GYPA MEN1 3302/4885KMT2A 266/4885ATM 3828/4885
US-20070073066-A1 Method for purifying dianhydrides AQP4, TRRAP, GYPA MEN1 3302/4885KMT2A 266/4885ATM 3828/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.