Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.43 |
| ▸ | HBB | P68871 | 1/20 | 0.43 |
| ▸ | P2RY6 | Q15077 | 2/20 | 0.36 |
| ▸ | P2RY14 | Q15391 | 2/20 | 0.36 |
| ▸ | NT5E | P21589 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | TK2 | O00142 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.31 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.31 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.31 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.31 |
| ▸ | GRIK5 | Q16478 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26792073 | 0.85 | LMNA (0.46) | LMNASMN1; SMN2MAPTTSHRPMP22 | |
| SCHEMBL26791628 | 0.84 | LMNA (0.39) | LMNASMN1; SMN2MAPTTSHRPMP22 | |
| SCHEMBL26268485 | 0.83 | LMNA (0.54) | LMNASMN1; SMN2MAPTTSHRPMP22 | |
| SCHEMBL26268441 | 0.83 | LMNA (0.44) | LMNASMN1; SMN2MAPTTSHRPMP22 | |
| SCHEMBL26268464 | 0.82 | LMNA (0.43) | LMNASMN1; SMN2MAPTTSHRPMP22 | |
| SCHEMBL26269167 | 0.82 | LMNA (0.46) | LMNASMN1; SMN2MAPTTSHRPMP22 | |
| SCHEMBL26791637 | 0.80 | SMN1; SMN2 (0.35) | LMNASMN1; SMN2MAPTTSHRPMP22 | |
| SCHEMBL26268794 | 0.80 | LMNA (0.39) | LMNASMN1; SMN2MAPTTSHRPMP22 | |
| SCHEMBL25400259 | 0.78 | TSHR (0.34) | LMNASMN1; SMN2MAPTTSHRPMP22 | |
| SCHEMBL25400267 | 0.78 | TSHR (0.34) | LMNASMN1; SMN2MAPTTSHRPMP22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230374058-A1 | COMPOUNDS AND METHODS FOR TREATING DISEASE | ROME THERAPEUTICS, INC. | 2023-11-23 | — | — | US | disclosed |
| US-20230295212-A1 | COMPOUNDS AND METHODS FOR TREATING DISEASE | ROME THERAPEUTICS INC (US) | 2023-09-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230295212-A1 | COMPOUNDS AND METHODS FOR TREATING DISEASE | EHMT1, POLRMT, RNASE1 | LMNA 2032/4885SMN1; SMN2 152/4885MAPT 147/4885 |
| US-20230374058-A1 | COMPOUNDS AND METHODS FOR TREATING DISEASE | EHMT1, POLRMT, RNASE1 | LMNA 2032/4885SMN1; SMN2 152/4885MAPT 147/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.