SCHEMBL2628155

SCHEMBL2628155

O=C(c1ccc(Cl)cc1)c1ccc(Oc2cccc3cc(Oc4ccc(C(=O)c5ccc(Oc6cccc7c(Oc8ccc(C(=O)c9ccc(Cl)cc9)cc8)cccc67)cc5)cc4)ccc23)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDR P35968 7/20 0.47
HPGD P15428 1/20 0.43
MCL1 Q07820 2/20 0.42
BCL2 P10415 1/20 0.42
BAD Q92934 1/20 0.42
AURKA O14965 1/20 0.42
LCK P06239 1/20 0.42
CSF1R P07333 1/20 0.42
MET P08581 1/20 0.42
BRAF P15056 1/20 0.42
FLT1 P17948 1/20 0.42
FGFR2 P21802 1/20 0.42
FLT4 P35916 1/20 0.42
TEK Q02763 1/20 0.42
AURKB Q96GD4 1/20 0.42
RHEB Q15382 1/20 0.41
MAPT P10636 2/20 0.41
POLB P06746 2/20 0.41
LMNA P02545 2/20 0.41
HTT P42858 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2628140 0.97 KDR (0.49) KDRHPGDMCL1BCL2BAD
SCHEMBL2628129 0.96 KDR (0.47) KDRHPGDMCL1BCL2BAD
SCHEMBL2628124 0.92 HPGD (0.45) KDRHPGDMCL1BCL2BAD
SCHEMBL2628146 0.91 KDR (0.45) KDRHPGDAURKALCKCSF1R
SCHEMBL2628125 0.89 LMNA (0.43) KDRHPGDMCL1BCL2BAD
SCHEMBL9452121 0.88 MEN1 (0.49) HPGDMCL1BCL2BADRHEB
SCHEMBL822946 0.88 HPGD (0.54) HPGDMCL1RHEBMAPTPOLB
SCHEMBL2628147 0.84 SIRT2 (0.47) KDRMCL1BCL2BADAURKA
SCHEMBL2628134 0.83 LMNA (0.50) HPGDMAPTPOLBLMNAHTT
SCHEMBL822859 0.82 MAPT (0.57) HPGDMCL1MAPTPOLBLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8163406-B2 Membrane-electrode assembly for solid polymer electrolyte fuel cell HONDA MOTOR CO., LTD. (JP) 2012-04-24 US disclosed
US-20080160381-A1 MEMBRANE-ELECTRODE ASSEMBLY FOR SOLID POLYMER ELECTROLYTE FUEL CELL HONDA MOTOR CO., LTD. (JP) 2008-07-03 US disclosed