Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 10/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.62 |
| ▸ | HPGD | P15428 | 3/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.62 |
| ▸ | TP53 | P04637 | 1/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.62 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.62 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.62 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.62 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.62 |
| ▸ | NPC1 | O15118 | 4/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11768650 | 0.92 | TTR (0.69) | TTRKDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL11322640 | 0.89 | TTR (0.80) | TTRKDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL11859861 | 0.89 | TTR (0.64) | TTRKDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL10623602 | 0.86 | TTR (0.83) | TTRKDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL11857659 | 0.85 | NPC1 (0.71) | TTRKDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL2628179 | 0.85 | NPC1 (0.52) | TTRKDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL23693962 | 0.84 | TTR (0.57) | TTRKDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL9980172 | 0.84 | ALPG (0.53) | KDM4EALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL10453744 | 0.84 | TTR (0.72) | TTRKDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL27147943 | 0.83 | TTR (0.53) | TTRKDM4EALDH1A1HPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8350041-B2 | Tricyclic δ-opioid modulators | JANSSEN PHARMACEUTICA, NV (BE) | 2013-01-08 | — | — | US | disclosed |
| US-20120095010-A1 | TRICYCLIC DELTA-OPIOID MODULATORS | CARSON JOHN R (US) | 2012-04-19 | — | — | US | disclosed |
| US-8106207-B2 | Tricyclic δ-opioid modulators | JANSSEN PHARMACEUTICA, NV (BE) | 2012-01-31 | — | — | US | disclosed |
| US-20110245291-A1 | TRICYCLIC DELTA-OPIOID MODULATORS | CARSON JOHN R | 2011-10-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120095010-A1 | TRICYCLIC DELTA-OPIOID MODULATORS | OPRD1, OPRK1, OPRL1 | TTR 2536/4885KDM4E 2174/4885ALDH1A1 1302/4885 |
| US-20110245291-A1 | TRICYCLIC DELTA-OPIOID MODULATORS | OPRD1, OPRK1, OPRL1 | TTR 2536/4885KDM4E 2174/4885ALDH1A1 1302/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.