Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAOX | Q6QHF9 | 4/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 2/20 | 0.41 |
| ▸ | ADH1B | P00325 | 1/20 | 0.41 |
| ▸ | ADH1C | P00326 | 1/20 | 0.41 |
| ▸ | ADH1A | P07327 | 1/20 | 0.41 |
| ▸ | ADH7 | P40394 | 1/20 | 0.41 |
| ▸ | S1PR2 | O95136 | 5/20 | 0.41 |
| ▸ | S1PR4 | O95977 | 5/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 5/20 | 0.41 |
| ▸ | S1PR3 | Q99500 | 5/20 | 0.41 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13616526 | 0.91 | PAOX (0.57) | PAOXTSHRALDH1A1EPHX1ADH1B | |
| SCHEMBL13616527 | 0.91 | PAOX (0.57) | PAOXTSHRALDH1A1EPHX1ADH1B | |
| SCHEMBL6655161 | 0.91 | PAOX (0.57) | PAOXTSHRALDH1A1EPHX1ADH1B | |
| SCHEMBL2628444 | 0.91 | PAOX (0.55) | PAOXTSHRALDH1A1EPHX1ALOX15 | |
| SCHEMBL2628454 | 0.88 | PAOX (0.64) | PAOXTSHRALDH1A1EPHX1CES1 | |
| SCHEMBL2628452 | 0.86 | PAOX (0.68) | PAOXTSHRALDH1A1EPHX1CES1 | |
| SCHEMBL23956968 | 0.85 | PAOX (0.59) | PAOXTSHRALDH1A1 | |
| Butanone SCHEMBL27943570 | 0.85 | ALDH1A1 (0.53) | PAOXTSHRALDH1A1EPHX1ALOX15 | |
| SCHEMBL15198689 | 0.85 | — | — | |
| Acetone SCHEMBL2671636 | 0.85 | TSHR (0.58) | PAOXTSHRALDH1A1EPHX1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9175037-B2 | Neuromedin U derivative | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2015-11-03 | — | — | US | disclosed |
| US-9175037-B2 | Neuromedin U derivative | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2015-11-03 | — | — | US | disclosed |
| EP-2418213-B1 | NEUROMEDIN U DERIVATIVE | TAKEDA PHARMACEUTICAL (JP) | 2014-11-19 | — | — | EP | disclosed |
| US-20120094899-A1 | NEUROMEDIN U DERIVATIVE | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-04-19 | — | — | US | disclosed |
| US-20120094899-A1 | NEUROMEDIN U DERIVATIVE | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-04-19 | — | — | US | disclosed |
| EP-2418213-A1 | NEUROMEDIN U DERIVATIVE | Takeda Pharmaceutical Company Limited (JP) | 2012-02-15 | — | — | EP | disclosed |
| US-20110212890-A1 | METASTIN DERIVATIVE AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-09-01 | — | — | US | disclosed |
| US-20110212890-A1 | METASTIN DERIVATIVE AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-09-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120094899-A1 | NEUROMEDIN U DERIVATIVE | NMUR1, NMUR2, NMBR | PAOX 1843/4885TSHR 4221/4885ALDH1A1 3304/4885 |
| US-20110212890-A1 | METASTIN DERIVATIVE AND USE THEREOF | GNRHR, SHBG, LHCGR | PAOX 4032/4885TSHR 1020/4885ALDH1A1 4055/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.