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Sugi Predict / Compounds / SCHEMBL2628685

SCHEMBL2628685

SCHEMBL2628685

Cc1cc(Br)ccc1NC(=O)[C@@H]1C[C@H](C)CC[C@H]1C(C)C

nearest known ligand 0.55

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ TRPM8 Q7Z2W7 4/20 0.55
▸ HPGD P15428 1/20 0.50
▸ HTT P42858 1/20 0.50
▸ AAK1 Q2M2I8 1/20 0.46
▸ MAPT P10636 2/20 0.44
▸ EPHX1 P07099 1/20 0.44
▸ SIGMAR1 Q99720 2/20 0.41
▸ ALDH1A1 P00352 1/20 0.40
▸ GAA P10253 1/20 0.40
▸ MEN1 O00255 2/20 0.40
▸ KMT2A Q03164 2/20 0.40
▸ LMNA P02545 1/20 0.40
▸ NPC1 O15118 1/20 0.39
▸ RAB9A P51151 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15133483 0.88 TRPM8 (0.57) TRPM8EPHX1MEN1KMT2ANPC1
SCHEMBL14664188 0.88 TRPM8 (0.57) TRPM8EPHX1MEN1KMT2ANPC1
SCHEMBL4817987 0.88 TRPM8 (0.57) TRPM8EPHX1MEN1KMT2ANPC1
SCHEMBL2628678 0.88 TRPM8 (0.57) TRPM8EPHX1MEN1KMT2ANPC1
SCHEMBL15133431 0.86 TRPM8 (0.55) TRPM8HTTMAPTEPHX1SIGMAR1
SCHEMBL5391878 0.86 TRPM8 (0.55) TRPM8EPHX1
SCHEMBL5384391 0.84 TRPM8 (0.53) TRPM8EPHX1
SCHEMBL10073868 0.84 TRPM8 (0.73) TRPM8EPHX1SIGMAR1MEN1KMT2A
SCHEMBL2628741 0.84 RAB9A (0.58) TRPM8HPGDMAPTEPHX1ALDH1A1
SCHEMBL4889806 0.83 TRPM8 (0.57) TRPM8HPGDEPHX1ALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20130190296-A1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF DISEASE ASSOCIATED WITH TRP-P8 EXPRESSION DENDREON CORPORATION (US) 2013-07-25 — — US disclosed
US-20130190296-A1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF DISEASE ASSOCIATED WITH TRP-P8 EXPRESSION DENDREON CORPORATION (US) 2013-07-25 — — US disclosed
US-8389730-B2 Compositions and methods for the treatment of disease associated with TRP-P8 expression DENDREON CORPORATION (US) 2013-03-05 — — US disclosed
US-8389730-B2 Compositions and methods for the treatment of disease associated with TRP-P8 expression DENDREON CORPORATION (US) 2013-03-05 — — US disclosed
US-20120094977-A1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF DISEASE ASSOCIATED WITH TRP-P8 EXPRESSION DENDREON CORPORATION (US) 2012-04-19 — — US disclosed
US-20120094977-A1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF DISEASE ASSOCIATED WITH TRP-P8 EXPRESSION DENDREON CORPORATION (US) 2012-04-19 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130190296-A1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF DISEASE ASSOCIATED WITH TRP-P8 EXPRESSION TRPC4, TRPC3, TRPC1 TRPM8 10/4885HPGD 2446/4885HTT 1421/4885
US-20120094977-A1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF DISEASE ASSOCIATED WITH TRP-P8 EXPRESSION TRPC4, TRPC3, TRPC1 TRPM8 8/4885HPGD 1277/4885HTT 1687/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.