Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.46 |
| ▸ | TRPM8 | Q7Z2W7 | 4/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.42 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.40 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14664228 | 1.00 | KMT2A (0.48) | KMT2AALDH1A1MEN1NPSR1SIGMAR1 | |
| SCHEMBL3392794 | 0.88 | TAAR1 (0.54) | KMT2AMEN1NPSR1TRPM8TAAR1 | |
| SCHEMBL1629039 | 0.88 | TAAR1 (0.54) | KMT2AMEN1NPSR1TRPM8TAAR1 | |
| SCHEMBL24540254 | 0.88 | TAAR1 (0.54) | KMT2AMEN1NPSR1TRPM8TAAR1 | |
| SCHEMBL15131620 | 0.86 | KMT2A (0.50) | KMT2AALDH1A1MEN1TRPM8TAAR1 | |
| SCHEMBL2628705 | 0.86 | KMT2A (0.50) | KMT2AALDH1A1MEN1TRPM8TAAR1 | |
| SCHEMBL4813136 | 0.81 | MC4R (0.52) | ALDH1A1NPSR1TRPM8EPHX1 | |
| SCHEMBL24677538 | 0.80 | CYP3A4 (0.47) | KMT2AALDH1A1MEN1NPSR1TRPM8 | |
| Hydrochloric Acid SCHEMBL29868258 | 0.79 | CYP3A4 (0.47) | KMT2AALDH1A1MEN1NPSR1TRPM8 | |
| SCHEMBL24540522 | 0.78 | TRPM8 (0.50) | KMT2AALDH1A1MEN1NPSR1TRPM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8389730-B2 | Compositions and methods for the treatment of disease associated with TRP-P8 expression | DENDREON CORPORATION (US) | 2013-03-05 | — | — | US | disclosed |
| US-8389730-B2 | Compositions and methods for the treatment of disease associated with TRP-P8 expression | DENDREON CORPORATION (US) | 2013-03-05 | — | — | US | disclosed |
| US-20120094977-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF DISEASE ASSOCIATED WITH TRP-P8 EXPRESSION | DENDREON CORPORATION (US) | 2012-04-19 | — | — | US | disclosed |
| US-20120094977-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF DISEASE ASSOCIATED WITH TRP-P8 EXPRESSION | DENDREON CORPORATION (US) | 2012-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120094977-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF DISEASE ASSOCIATED WITH TRP-P8 EXPRESSION | TRPC4, TRPC3, TRPC1 | KMT2A 4664/4885ALDH1A1 4742/4885MEN1 2516/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.