Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 5/20 | 0.47 |
| ▸ | TSHR | P16473 | 5/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | MC4R | P32245 | 1/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | SERPINE1 | P05121 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | F2 | P00734 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL29868258 | 0.99 | CYP3A4 (0.47) | CYP3A4TSHRCYP2C9CYP2C19CYP2D6 | |
| SCHEMBL4813136 | 0.91 | MC4R (0.52) | CYP3A4TSHRCYP2C9CYP2C19CYP2D6 | |
| SCHEMBL24677482 | 0.89 | TRPM8 (0.48) | CYP3A4TSHRCYP2C9CYP2C19CYP2D6 | |
| Hydrochloric Acid SCHEMBL29868121 | 0.88 | TRPM8 (0.47) | CYP3A4TSHRCYP2C9CYP2C19CYP2D6 | |
| SCHEMBL24540769 | 0.84 | SERPINE1 (0.48) | CYP3A4TSHRCYP2C9CYP2C19CYP2D6 | |
| SCHEMBL4886347 | 0.83 | SERPINE1 (0.59) | SMN1; SMN2ALDH1A1TRPM8HPGDSERPINE1 | |
| SCHEMBL31448505 | 0.83 | ALDH1A1 (0.55) | LMNASMN1; SMN2ALDH1A1TRPM8HPGD | |
| SCHEMBL15133430 | 0.83 | ALDH1A1 (0.55) | LMNASMN1; SMN2ALDH1A1TRPM8HPGD | |
| SCHEMBL24677403 | 0.82 | TRPM8 (0.50) | ALDH1A1TRPM8SERPINE1 | |
| SCHEMBL24677412 | 0.82 | TRPM8 (0.50) | SMN1; SMN2ALDH1A1TRPM8HPGDSERPINE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022178030-A1 | TRPM8 AGONISTS AS COOLING AGENTS AND FOR THE TREATMENT OF DISEASE | Concentric Analgesics, Inc. (US) | 2022-08-25 | — | — | WO | disclosed |