SCHEMBL26313137

SCHEMBL26313137

COc1ccc(Cn2cc(-c3cc(C(F)F)nc(SC)n3)ccc2=O)cc1C(F)(F)F

nearest known ligand 0.52

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
▸ SDHB P21912 20/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19805843 0.91 SDHB (0.55) SDHB
SCHEMBL26313133 0.89 SDHB (0.47) SDHB
SCHEMBL20985630 0.85 SDHB (0.70) SDHB
SCHEMBL20985644 0.84 SDHB (0.51) SDHB
SCHEMBL30526081 0.84 SDHB (0.51) SDHB
SCHEMBL20985664 0.82 SDHB (0.42) SDHB
SCHEMBL19805988 0.81 SDHB (0.53) SDHB
SCHEMBL19806088 0.79 SDHB (0.54) SDHB
SCHEMBL23897424 0.79 SDHB (0.64) SDHB
SCHEMBL21019932 0.79 SDHB (0.58) SDHB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11725000-B2 Apoptosis inhibitors NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) 2023-08-15 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11725000-B2 Apoptosis inhibitors BAX, SDHA, SDHB SDHB 3/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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