Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MET | P08581 | 4/20 | 0.36 |
| ▸ | GNRHR | P30968 | 1/20 | 0.35 |
| ▸ | METAP2 | P50579 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22617566 | 0.84 | ALDH1A1 (0.40) | ALDH1A1SMN1; SMN2MAPTATMHTT | |
| SCHEMBL20932780 | 0.81 | ALDH1A1 (0.39) | ALDH1A1SMN1; SMN2MAPTATMHTT | |
| SCHEMBL21497381 | 0.80 | PRKCZ (0.35) | MAPTTRPV1CYP3A4CYP2D6SLC6A2 | |
| SCHEMBL264293 | 0.80 | ALDH1A1 (0.58) | ALDH1A1SMN1; SMN2MAPTATMHTT | |
| SCHEMBL19750751 | 0.77 | MAPT (0.38) | ALDH1A1SMN1; SMN2MAPTATMHTT | |
| SCHEMBL21497380 | 0.77 | GNRHR (0.41) | ALDH1A1SMN1; SMN2MAPTATMHTT | |
| SCHEMBL22078503 | 0.76 | PDE10A (0.35) | ALDH1A1SMN1; SMN2MAPTATMHTT | |
| SCHEMBL19424168 | 0.75 | PDE10A (0.45) | METAP2TRPV1SLC6A4PDE10A | |
| SCHEMBL10285521 | 0.74 | ALDH1A1 (0.51) | ALDH1A1SMN1; SMN2MAPTATMHTT | |
| SCHEMBL24904290 | 0.74 | MAPT (0.38) | ALDH1A1SMN1; SMN2MAPTATMHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230278993-A1 | NOVEL TRICYCLIC AROMATIC HETEROCYCLIC COMPOUND AND PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION AND USE THEREOF | SHANGHAI LONGWOOD BIOPHARMACEUTICALS CO., LTD. (CN) | 2023-09-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230278993-A1 | NOVEL TRICYCLIC AROMATIC HETEROCYCLIC COMPOUND AND PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION AND USE THEREOF | PDCD1, CD274, PDCD1LG2 | ALDH1A1 216/4885SMN1; SMN2 3869/4885MAPT 578/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.