Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 2/20 | 0.37 |
| ▸ | ATR | Q13535 | 2/20 | 0.35 |
| ▸ | ATRIP | Q8WXE1 | 2/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.35 |
| ▸ | EGFR | P00533 | 3/20 | 0.33 |
| ▸ | GRM5 | P41594 | 2/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.33 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.33 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.33 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.33 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.33 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.31 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | CDK1 | P06493 | 1/20 | 0.31 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | AKT1 | P31749 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29536029 | 0.78 | CDC7 (0.41) | CDC7GRM5ROCK2ROCK1 | |
| SCHEMBL21900948 | 0.78 | CDC7 (0.41) | CDC7GRM5ROCK2ROCK1 | |
| SCHEMBL21901248 | 0.75 | GRM5 (0.37) | CDC7GRM5MAPK1AKT1GSK3B | |
| SCHEMBL21900957 | 0.74 | PGK1 (0.38) | CDC7DAPK3DYRK3ROCK2CDK1 | |
| SCHEMBL21856683 | 0.74 | AXL (0.40) | CDC7DAPK3DYRK3ROCK2CDK1 | |
| SCHEMBL29536009 | 0.71 | MAOB (0.39) | GRM5ROCK2MAPK1ROCK1 | |
| SCHEMBL22688255 | 0.71 | MAOB (0.39) | GRM5ROCK2MAPK1ROCK1 | |
| SCHEMBL21900955 | 0.70 | PDGFRB (0.36) | GRM5ROCK2ROCK1 | |
| SCHEMBL26321523 | 0.70 | ALDH1A1 (0.38) | CDC7DAPK3DYRK3ROCK2CDK1 | |
| SCHEMBL23887925 | 0.69 | MKNK1 (0.37) | EGFRROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230279010-A1 | PROCESSES FOR PREPARING MODULATORS OF ALPHA-1 ANTITRYPSIN | VERTEX PHARMACEUTICALS INCORPORATED | 2023-09-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230279010-A1 | PROCESSES FOR PREPARING MODULATORS OF ALPHA-1 ANTITRYPSIN | SERPINA2, SERPINC1, SERPINE1 | CDC7 4596/4885ATR 4468/4885ATRIP 2945/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.