SCHEMBL263230

SCHEMBL263230

OCc1cccc2c1Cc1ccccc1-2

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PNMT P11086 1/20 0.68
DRD2 P14416 1/20 0.48
DRD4 P21917 1/20 0.48
DRD3 P35462 1/20 0.48
PGR P06401 1/20 0.47
NPC1 O15118 3/20 0.46
RAB9A P51151 3/20 0.46
PDCD1 Q15116 1/20 0.43
CD274 Q9NZQ7 1/20 0.43
HTR7 P34969 1/20 0.43
HTR2B P41595 1/20 0.43
CHEK1 O14757 1/20 0.41
CA1 P00915 2/20 0.41
CA2 P00918 2/20 0.41
CA4 P22748 2/20 0.41
CA6 P23280 2/20 0.41
MAOA P21397 1/20 0.38
KDM4E B2RXH2 2/20 0.36
ALDH1A1 P00352 2/20 0.36
MAPT P10636 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28726783 0.91 PNMT (0.61) PNMTDRD2DRD4DRD3PGR
Acetic Acid SCHEMBL28541738 0.90 PNMT (0.57) PNMTDRD2DRD4DRD3PGR
SCHEMBL1567178 0.85 PNMT (0.64) PNMTDRD2DRD4DRD3PGR
SCHEMBL7195192 0.84 PNMT (0.72) PNMTDRD2DRD4DRD3PGR
SCHEMBL5366733 0.84 PNMT (0.72) PNMTDRD2DRD4DRD3PGR
SCHEMBL11000829 0.83 PNMT (0.47) PNMTDRD2PGRNPC1RAB9A
SCHEMBL7609046 0.82 PNMT (0.70) PNMTDRD2DRD4DRD3PGR
SCHEMBL7603814 0.82 PNMT (0.70) PNMTDRD2DRD4DRD3PGR
SCHEMBL9859906 0.82 PNMT (0.70) PNMTDRD2DRD4DRD3PGR
SCHEMBL7607164 0.82 PNMT (0.70) PNMTDRD2DRD4DRD3PGR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 816 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119390724-A Synthesis method of phosphorous acid diester compound 兰州大学 2025-02-07 CN claimed
CN-118084613-A Method for synthesizing 9, 9-bis (hydroxymethyl) fluorene SABIC环球技术有限责任公司 2024-05-28 CN claimed
CN-117924154-A Preparation method of piperidine-2-formate compound 浙江九洲药业股份有限公司 2024-04-26 CN claimed
CN-117658781-A Preparation method of 9, 9-bis (hydroxymethyl) fluorene 中国石油天然气股份有限公司 2024-03-08 CN claimed
CN-116120333-B Podophyllotoxin nano prodrug and preparation method and application thereof 沈阳药科大学 2024-01-26 CN claimed
CN-116685576-A Cysteine protease inhibitors and methods of use thereof 美商帕迪斯生物科学公司 2023-09-01 CN claimed
US-20230212152-A1 INHIBITORS OF CYSTEINE PROTEASES AND METHODS OF USE THEREOF Pardes Biosciences, Inc. 2023-07-06 US claimed
CN-116120333-A Podophyllotoxin nano prodrug and preparation method and application thereof 沈阳药科大学 2023-05-16 CN claimed
EP-4161902-A1 INHIBITORS OF CYSTEINE PROTEASES AND METHODS OF USE THEREOF Pardes Biosciences, Inc. (US) 2023-04-12 EP claimed
CN-113354514-B Method for controllable high-selectivity synthesis of 9-fluorenylmethanol and 9, 9-bis-hydroxymethyl fluorene 太原理工大学 2023-04-07 CN claimed
EP-0245662-B1 P-HYDROXYPHENYLSULFONIUM SALTS AND THEIR USE IN THE PREPARATION OF ESTERS AND AMIDES SANSHIN KAGAKU KOGYO CO., LTD. (JP) 1991-08-07 EP claimed
US-5008205-A Method of facilitating detection of amino acid derivatives with enhanced sensitivity HEWLETT-PACKARD COMPANY (US) 1991-04-16 US claimed
EP-0406567-A2 Process for the production of sulfonium compounds and novel methylthiophenol derivatives MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 1991-01-09 EP claimed
EP-0217688-B1 PEPTIDE DERIVATIVES WITH A LACTONIC OR CYCLOAMIDIC STRUCTURE, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM ADIR ET COMPAGNIE (FR) 1990-09-26 EP claimed
EP-0375047-A2 New process for the synthesis of N alpha-fluorenylmethoxycarbonyl-Ng-trityl-arginine SCLAVO S.p.A. (IT) 1990-06-27 EP claimed
EP-0346756-A1 Process for production of sulfonium compounds MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 1989-12-20 EP claimed
EP-0331988-A1 Sulfonium compounds, as well as process for producing active esters and amides used for the production of amides SANSHIN KAGAKU KOGYO CO., LTD. (JP) 1989-09-13 EP claimed
US-4857656-A Active esters used for production of esters or amides and process for producing esters or amides SANSHIN KAGAKU KOGYO CO., LTD. (JP) 1989-08-15 US claimed
EP-0245662-A1 p-Hydroxyphenylsulfonium salts and their use in the preparation of esters and amides SANSHIN KAGAKU KOGYO CO., LTD. (JP) 1987-11-19 EP claimed
EP-0217688-A1 Peptide derivatives with a lactonic or cycloamidic structure, process for their preparation and pharmaceutical compositions containing them ADIR ET COMPAGNIE (FR) 1987-04-08 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230212152-A1 INHIBITORS OF CYSTEINE PROTEASES AND METHODS OF USE THEREOF CTRL, CTSL, CTSV PNMT 4164/4885DRD2 4609/4885DRD4 4772/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.