Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | MLYCD | O95822 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.34 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | BTN3A1 | O00481 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25440061 | 0.86 | TSHR (0.40) | TSHRNR1I2NR1H2NR1H3SMN1; SMN2 | |
| SCHEMBL26324864 | 0.82 | KMT2A (0.34) | TSHRBTN3A1MMP2MMP9MMP8 | |
| SCHEMBL26324941 | 0.81 | TSHR (0.46) | TSHRSMN1; SMN2CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL26324890 | 0.78 | ALDH1A1 (0.39) | TSHRSMN1; SMN2GAALMNAMAPT | |
| SCHEMBL26324920 | 0.78 | TSHR (0.44) | TSHRCHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL11680056 | 0.77 | KCNH2 (0.42) | NR1I2NR1H2NR1H3SMN1; SMN2MLYCD | |
| SCHEMBL26324800 | 0.76 | TSHR (0.42) | TSHRSMN1; SMN2GAACHRNB2CHRNB4 | |
| SCHEMBL26324873 | 0.75 | TSHR (0.41) | TSHRSMN1; SMN2GAACHRNB2CHRNB4 | |
| SCHEMBL26324862 | 0.74 | BTN3A1 (0.39) | TSHRSMN1; SMN2GAACHRNB2CHRNB4 | |
| SCHEMBL11679086 | 0.73 | NR1I2 (0.44) | NR1I2NR1H2NR1H3SMN1; SMN2MLYCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11767291-B2 | Preparation of secondary amines with electrophilic N-linchpin reagents | WILLIAM MARSH RICE UNIVERSITY (US) | 2023-09-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11767291-B2 | Preparation of secondary amines with electrophilic N-linchpin reagents | PNMT, NCL, NPM1 | TSHR 2716/4885NR1I2 3981/4885NR1H2 3952/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.