SCHEMBL26326502

SCHEMBL26326502

C1=Cc2c(oc3cccc(-c4cc(-c5nc(-c6ccccc6)nc(-c6ccccc6)n5)c5c(c4)oc4ccccc45)c23)CC1

nearest known ligand 0.33

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.31
LMNA P02545 1/20 0.31
POLB P06746 1/20 0.31
MAPT P10636 1/20 0.31
HTT P42858 1/20 0.31
KMT2A Q03164 1/20 0.31
BACE1 P56817 1/20 0.30
ADORA3 P0DMS8 1/20 0.30
ALOX15 P16050 1/20 0.30
ADORA2A P29274 1/20 0.30
ADORA2B P29275 1/20 0.30
ADORA1 P30542 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24971380 0.98 BACE1 (0.31) TSHRLMNAPOLBMAPTHTT
SCHEMBL25652508 0.95 LMNA (0.31) TSHRLMNAPOLBMAPTHTT
SCHEMBL26292290 0.94 KDM4E (0.31) KMT2A
SCHEMBL23445288 0.89 TSHR (0.30) TSHRMAPTADORA3ALOX15ADORA2A
SCHEMBL24973225 0.89 TSHR (0.32) TSHRMAPTADORA3ALOX15ADORA2A
SCHEMBL24586674 0.88
SCHEMBL24314671 0.88 TSHR (0.31) TSHRLMNAPOLBMAPTHTT
SCHEMBL27390831 0.87 PLA2G2A (0.34)
SCHEMBL24973672 0.87 TSHR (0.31) TSHRBACE1
SCHEMBL24315237 0.87

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4243102-A1 ORGANIC LIGHT-EMITTING DEVICE Lg Chem, Ltd. (KR) 2023-09-13 EP disclosed