Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD1 | P21728 | 19/20 | 0.85 |
| ▸ | DRD2 | P14416 | 14/20 | 0.85 |
| ▸ | DRD3 | P35462 | 12/20 | 0.85 |
| ▸ | DRD5 | P21918 | 5/20 | 0.85 |
| ▸ | F3 | P13726 | 3/20 | 0.85 |
| ▸ | HTR1A | P08908 | 3/20 | 0.85 |
| ▸ | DRD4 | P21917 | 3/20 | 0.84 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.84 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.80 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.80 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.80 |
| ▸ | HTR2A | P28223 | 1/20 | 0.69 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.69 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.69 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.69 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.69 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12630238 | 0.92 | DRD1 (0.79) | DRD1DRD2DRD3DRD5F3 | |
| Corydalmine SCHEMBL12667453 | 0.92 | DRD1 (1.00) | DRD1DRD2DRD3DRD5F3 | |
| Corydalmine SCHEMBL21192512 | 0.92 | DRD1 (1.00) | DRD1DRD2DRD3DRD5F3 | |
| Corydalmine SCHEMBL29243055 | 0.91 | DRD1 (0.98) | DRD1DRD2DRD3DRD5F3 | |
| Stepholidine SCHEMBL10001965 | 0.91 | DRD1 (1.00) | DRD1DRD2DRD3DRD5F3 | |
| Stepholidine SCHEMBL460434 | 0.91 | DRD1 (1.00) | DRD1DRD2DRD3DRD5F3 | |
| Stepholidine SCHEMBL29943869 | 0.91 | DRD1 (1.00) | DRD1DRD2DRD3DRD5F3 | |
| Stepholidine SCHEMBL10001966 | 0.91 | DRD1 (1.00) | DRD1DRD2DRD3DRD5F3 | |
| Stepholidine SCHEMBL29414100 | 0.91 | DRD1 (1.00) | DRD1DRD2DRD3DRD5F3 | |
| SCHEMBL20759563 | 0.90 | DRD1 (0.84) | DRD1DRD2DRD3DRD5F3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11731965-B2 | Tetrahydroprotoberberine compound, preparation method therefor and uses thereof, and pharmaceutical composition | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2023-08-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11731965-B2 | Tetrahydroprotoberberine compound, preparation method therefor and uses thereof, and pharmaceutical composition | NOTUM, BHMT, CYP4F11 | DRD1 448/4885DRD2 682/4885DRD3 834/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.