Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD1 | P21728 | 20/20 | 1.00 |
| ▸ | DRD2 | P14416 | 15/20 | 1.00 |
| ▸ | DRD3 | P35462 | 14/20 | 1.00 |
| ▸ | DRD5 | P21918 | 4/20 | 1.00 |
| ▸ | F3 | P13726 | 3/20 | 1.00 |
| ▸ | DRD4 | P21917 | 2/20 | 1.00 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 1.00 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.91 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.91 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.91 |
| ▸ | HTR1A | P08908 | 1/20 | 0.89 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.78 |
| ▸ | LMNA | P02545 | 1/20 | 0.78 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.78 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.78 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.78 |
| ▸ | CASP1 | P29466 | 1/20 | 0.78 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.78 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Stepholidine SCHEMBL460434 | 1.00 | DRD1 (1.00) | DRD1DRD2DRD3DRD5F3 | |
| Stepholidine SCHEMBL10001965 | 1.00 | DRD1 (1.00) | DRD1DRD2DRD3DRD5F3 | |
| Stepholidine SCHEMBL29414100 | 1.00 | DRD1 (1.00) | DRD1DRD2DRD3DRD5F3 | |
| Stepholidine SCHEMBL29943869 | 1.00 | DRD1 (1.00) | DRD1DRD2DRD3DRD5F3 | |
| Corydalmine SCHEMBL21192512 | 0.94 | DRD1 (1.00) | DRD1DRD2DRD3DRD5F3 | |
| Corydalmine SCHEMBL12667453 | 0.94 | DRD1 (1.00) | DRD1DRD2DRD3DRD5F3 | |
| Corydalmine SCHEMBL29243055 | 0.93 | DRD1 (0.98) | DRD1DRD2DRD3DRD5F3 | |
| SCHEMBL14703846 | 0.93 | DRD1 (1.00) | DRD1DRD2DRD3DRD5F3 | |
| SCHEMBL680031 | 0.93 | DRD1 (1.00) | DRD1DRD2DRD3DRD5F3 | |
| SCHEMBL29561422 | 0.93 | DRD1 (1.00) | DRD1DRD2DRD3DRD5F3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122018362-A | HIL-based distributed drive chassis control method | 厦门理工学院 | 2026-05-12 | — | — | CN | disclosed |
| CN-112292042-B | Crystalline starch decomposition product and application thereof | 昭和产业株式会社 | 2024-03-01 | — | — | CN | disclosed |
| EP-3517537-B1 | DEUTERATED DERIVATIVE OF L-TETRAHYDROPALMATINE AND MEDICAL USE THEREOF | TAIZHOU HUAYUAN MEDICINAL TECH CO LTD (CN) | 2023-09-13 | — | — | EP | disclosed |
| EP-3517537-B1 | DEUTERATED DERIVATIVE OF L-TETRAHYDROPALMATINE AND MEDICAL USE THEREOF | TAIZHOU HUAYUAN MEDICINAL TECH CO LTD (CN) | 2023-09-13 | — | — | EP | disclosed |
| US-11731965-B2 | Tetrahydroprotoberberine compound, preparation method therefor and uses thereof, and pharmaceutical composition | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2023-08-22 | — | — | US | disclosed |
| US-11731965-B2 | Tetrahydroprotoberberine compound, preparation method therefor and uses thereof, and pharmaceutical composition | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2023-08-22 | — | — | US | disclosed |
| CN-218974476-U | Quick detection circuit of surge protector | 麦王照明电器(上海)有限公司 | 2023-05-05 | — | — | CN | disclosed |
| WO-2023068231-A1 | FOOD COMPOSITION, DRIED MATERIAL AND POWDERIZATION METHOD | 株式会社ユーグレナ | 2023-04-27 | — | — | WO | disclosed |
| US-20230037875-A1 | SACCHARIDE FRUIT BEVERAGE HAVING IMPROVED FLAVOR AND METHOD FOR PRODUCING THE SAME | KIRIN HOLDINGS KABUSHIKI KAISHA (JP) | 2023-02-09 | — | — | US | disclosed |
| US-11420773-B2 | Engine thrust rating architecture and processes | THE BOEING COMPANY (US) | 2022-08-23 | — | — | US | disclosed |
| EP-3517537-A1 | DEUTERATED DERIVATIVE OF L-TETRAHYDROPALMATINE AND MEDICAL USE THEREOF | Jingluweidai Information Consulting Service (Beijing) Co Ltd (CN) | 2019-07-31 | — | — | EP | disclosed |
| WO-2019034031-A1 | TETRAHYDROPROTOBERBERINE COMPOUND, PREPARATION METHOD THEREFOR AND USES THEREOF, AND PHARMACEUTICAL COMPOSITION | 中国科学院上海药物研究所 | 2019-02-21 | — | — | WO | disclosed |
| US-20170100389-A1 | TETRAHYDROPROTOBERBINE COMPOUNDS AND USES THEREOF IN THE TREATMENT OF NEUROLOGICAL, PSYCHIATRIC AND NEURODEGENERATIVE DISEASES | MILLER JAMES JACKSON (CA) | 2017-04-13 | — | — | US | disclosed |
| US-9526721-B2 | Tetrahydroprotoberbine compounds and uses thereof in the treatment of neurological, psychiatric and neurodegenerative diseases | MILLER JAMES JACKSON (CA) | 2016-12-27 | — | — | US | disclosed |
| US-20150306092-A1 | TETRAHYDROPROTOBERBINE COMPOUNDS AND USES THEREOF IN THE TREATMENT OF NEUROLOGICAL, PSYCHIATRIC AND NEURODEGENERATIVE DISEASES | MILLER JAMES JACKSON (CA) | 2015-10-29 | — | — | US | disclosed |
| US-8501762-B2 | Tetrahydroprotoberberine compounds, the synthetic method and the use thereof | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2013-08-06 | — | — | US | disclosed |
| US-8501762-B2 | Tetrahydroprotoberberine compounds, the synthetic method and the use thereof | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2013-08-06 | — | — | US | disclosed |
| WO-2012031573-A1 | A METHOD FOR PREPARING AN OPTICAL ISOMERIC STEPHOLIDINE AND DERIVATES THEREOF | 山东特珐曼医药原料有限公司 (CN) | 2012-03-15 | — | — | WO | disclosed |
| US-20110060045-A1 | ANTI-DIABETIC CATARACT COMPOUNDS AND THEIR USES | NATIONAL RESEARCH COUNCIL OF CANADA (CA) | 2011-03-10 | — | — | US | disclosed |
| US-20090149488-A1 | Tetrahydroprotoberberine Compounds, the Synthetic Method and the Use Thereof | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCE (CN) | 2009-06-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170100389-A1 | TETRAHYDROPROTOBERBINE COMPOUNDS AND USES THEREOF IN THE TREATMENT OF NEUROLOGICAL, PSYCHIATRIC AND NEURODEGENERATIVE DISEASES | HTR1B, HTR2B, MAOB | DRD1 124/4885DRD2 63/4885DRD3 258/4885 |
| US-20110060045-A1 | ANTI-DIABETIC CATARACT COMPOUNDS AND THEIR USES | INSR, GPR119, ADRB1 | DRD1 1085/4885DRD2 1564/4885DRD3 784/4885 |
| US-11731965-B2 | Tetrahydroprotoberberine compound, preparation method therefor and uses thereof, and pharmaceutical composition | NOTUM, BHMT, CYP4F11 | DRD1 448/4885DRD2 682/4885DRD3 834/4885 |
| US-20150306092-A1 | TETRAHYDROPROTOBERBINE COMPOUNDS AND USES THEREOF IN THE TREATMENT OF NEUROLOGICAL, PSYCHIATRIC AND NEURODEGENERATIVE DISEASES | HTR1B, HTR2B, MAOB | DRD1 119/4885DRD2 64/4885DRD3 259/4885 |
| US-20090149488-A1 | Tetrahydroprotoberberine Compounds, the Synthetic Method and the Use Thereof | CNR1, AVPR1B, MTNR1B | DRD1 47/4885DRD2 20/4885DRD3 98/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.