Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 2/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | PRKACA | P17612 | 1/20 | 0.47 |
| ▸ | SORD | Q00796 | 2/20 | 0.44 |
| ▸ | DUSP10 | Q9Y6W6 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | F11 | P03951 | 1/20 | 0.37 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.36 |
| ▸ | IDH1 | O75874 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2625467 | 0.82 | AURKA (0.53) | ADORA2AAURKAHSP90AA1PRKACASORD | |
| SCHEMBL12386863 | 0.73 | ASIC3 (0.47) | KMT2ARAB9AADORA1KDM4EMAPT | |
| SCHEMBL21969502 | 0.73 | SORD (0.38) | SORDKMT2ARAB9AKDM4EMAPT | |
| SCHEMBL25888171 | 0.72 | SORD (0.38) | SORDRAB9AL3MBTL1NPC1ALDH1A1 | |
| SCHEMBL22655921 | 0.72 | TAAR1 (0.36) | SORD | |
| SCHEMBL10272516 | 0.72 | AURKA (0.53) | ADORA2AAURKAHSP90AA1PRKACADUSP10 | |
| SCHEMBL22681512 | 0.72 | SORD (0.33) | SORD | |
| SCHEMBL13053048 | 0.72 | L3MBTL1 (0.50) | ADORA2AMEN1KMT2ARAB9AADORA1 | |
| SCHEMBL13062429 | 0.72 | SORD (0.33) | SORD | |
| SCHEMBL13663803 | 0.71 | TSHR (0.38) | MEN1KMT2ARAB9AL3MBTL1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8163763-B2 | Pyrimidine compounds, compositions and methods of use | GENENTECH, INC. (US) | 2012-04-24 | — | — | US | disclosed |