SCHEMBL26327982

SCHEMBL26327982

CC(O)(c1ccc(Oc2ccc(N)c(C(O)(C(F)(F)F)C(F)(F)F)c2)cc1N)C(F)(F)F

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.51
NR4A1 P22736 1/20 0.40
MEN1 O00255 3/20 0.34
KMT2A Q03164 3/20 0.34
KDM4E B2RXH2 2/20 0.34
MAPT P10636 2/20 0.34
MAPK1 P28482 2/20 0.34
LMNA P02545 1/20 0.34
HTT P42858 1/20 0.34
NPSR1 Q6W5P4 1/20 0.34
HSD17B10 Q99714 2/20 0.33
ALDH1A1 P00352 1/20 0.33
GLA P06280 1/20 0.33
POLB P06746 1/20 0.33
GAA P10253 1/20 0.33
HPGD P15428 1/20 0.33
ATM Q13315 1/20 0.33
HSD11B1 P28845 1/20 0.33
AR P10275 4/20 0.33
KCNJ11 Q14654 3/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15746148 0.90 SMN1; SMN2 (0.54) SMN1; SMN2NR4A1MEN1KMT2AKDM4E
SCHEMBL15745076 0.89 NR4A1 (0.42) SMN1; SMN2NR4A1MAPTMAPK1ALDH1A1
SCHEMBL10002083 0.87 SMN1; SMN2 (0.45) SMN1; SMN2NR4A1MEN1KMT2AMAPT
SCHEMBL10036669 0.87 SMN1; SMN2 (0.61) SMN1; SMN2NR4A1MEN1KMT2AKDM4E
SCHEMBL13294535 0.82 SMN1; SMN2 (0.56) SMN1; SMN2NR4A1MEN1KMT2AKDM4E
SCHEMBL13588163 0.81 SMN1; SMN2 (0.69) SMN1; SMN2NR4A1MEN1KMT2AKDM4E
SCHEMBL13588164 0.81 SMN1; SMN2 (0.59) SMN1; SMN2NR4A1MEN1KMT2AKDM4E
SCHEMBL10002093 0.81 ALDH1A1 (0.45) SMN1; SMN2NR4A1MEN1KMT2AMAPT
SCHEMBL10036539 0.81 SMN1; SMN2 (0.54) SMN1; SMN2NR4A1MEN1KMT2AKDM4E
SCHEMBL26327980 0.78 SMN1; SMN2 (0.51) SMN1; SMN2MEN1KMT2AKDM4EMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230287178-A1 Fluorinated Diamine or Salt Thereof, Method for Producing Fluorinated Diamine or Salt Thereof, Polyamide, Method for Producing Polyamide, Polyamide Solution, Cyclized Polyamide, Method for Producing Cyclized Polyamide, Insulation for High-Frequency Electronic Component, Method for Producing Insulation for High-Frequency Electronic Component, High-Frequency Electronic Component, High-Frequency Appliance, and Insulating Material for Producing High-Frequency Electronic Component CENTRAL GLASS COMPANY, LIMITED (JP) 2023-09-14 US disclosed