Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DOT1L | Q8TEK3 | 2/20 | 0.37 |
| ▸ | POLRMT | O00411 | 1/20 | 0.37 |
| ▸ | ADK | P55263 | 2/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.35 |
| ▸ | AHCY | P23526 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26832176 | 0.93 | POLRMT (0.39) | DOT1LPOLRMT | |
| SCHEMBL26832023 | 0.86 | POLRMT (0.40) | DOT1LPOLRMT | |
| SCHEMBL26832481 | 0.84 | POLRMT (0.38) | DOT1LPOLRMT | |
| SCHEMBL26832290 | 0.84 | POLRMT (0.39) | DOT1LPOLRMTAHCY | |
| SCHEMBL26319911 | 0.83 | POLRMT (0.37) | DOT1LPOLRMT | |
| SCHEMBL26398893 | 0.82 | POLRMT (0.36) | DOT1LPOLRMT | |
| SCHEMBL26149119 | 0.82 | POLRMT (0.40) | DOT1LPOLRMT | |
| SCHEMBL26239628 | 0.81 | POLRMT (0.44) | DOT1LPOLRMTAHCY | |
| SCHEMBL26148725 | 0.81 | POLRMT (0.39) | DOT1LPOLRMT | |
| SCHEMBL26239615 | 0.81 | DOT1L (0.36) | DOT1LPOLRMTAHCY |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230279014-A1 | COMPOUNDS AND METHODS FOR TREATMENT OF VIRAL INFECTIONS | GILEAD SCIENCES, INC. | 2023-09-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230279014-A1 | COMPOUNDS AND METHODS FOR TREATMENT OF VIRAL INFECTIONS | HAVCR2, EIF2AK2, OAT | DOT1L 2112/4885POLRMT 16/4885ADK 2870/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.