Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VDR | P11473 | 2/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | GPBAR1 | Q8TDU6 | 4/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.46 |
| ▸ | POLA1 | P09884 | 1/20 | 0.46 |
| ▸ | TOP2A | P11388 | 1/20 | 0.46 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.45 |
| ▸ | NPC1L1 | Q9UHC9 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17317988 | 0.90 | GPBAR1 (0.65) | VDRUSP2GPBAR1CYP2C9HIF1A | |
| SCHEMBL14056665 | 0.90 | GPBAR1 (0.65) | VDRUSP2GPBAR1CYP2C9HIF1A | |
| SCHEMBL16163667 | 0.88 | USP2 (0.50) | VDRUSP2GPBAR1POLA1TOP2A | |
| SCHEMBL6300887 | 0.88 | NPC1L1 (0.55) | VDRUSP2POLA1NPC1L1 | |
| SCHEMBL16163620 | 0.88 | NPC1L1 (0.55) | VDRUSP2POLA1NPC1L1 | |
| SCHEMBL6300889 | 0.88 | NPC1L1 (0.55) | VDRUSP2POLA1NPC1L1 | |
| SCHEMBL14976644 | 0.88 | USP2 (0.50) | VDRUSP2GPBAR1POLA1TOP2A | |
| SCHEMBL6303110 | 0.88 | NPC1L1 (0.55) | VDRUSP2POLA1NPC1L1 | |
| SCHEMBL9133868 | 0.88 | NPC1L1 (0.55) | VDRUSP2POLA1NPC1L1 | |
| SCHEMBL19293662 | 0.84 | VDR (0.54) | VDRUSP2GPBAR1CYP2C9HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4306114-A1 | OXYSTEROLS AND METHODS OF USE THEREOF | Sage Therapeutics, Inc. (US) | 2024-01-17 | — | — | EP | disclosed |
| EP-3157528-B1 | OXYSTEROLS AND METHODS OF USE THEREOF | SAGE THERAPEUTICS INC (US) | 2023-09-13 | — | — | EP | disclosed |