Known targets — ChEMBL curated mechanism
KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2
The experimentally established mechanism targets of Guanidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Guanidine SCHEMBL27804491 | 0.95 | — | — | |
| 1,3-Propanediol SCHEMBL18246837 | 0.82 | — | — | |
| Guanidine SCHEMBL27596870 | 0.82 | — | — | |
| Propanol SCHEMBL4327260 | 0.79 | — | — | |
| Guanidine SCHEMBL998384 | 0.79 | — | — | |
| Guanidine SCHEMBL5613752 | 0.78 | — | — | |
| Guanidine SCHEMBL29983942 | 0.78 | — | — | |
| Guanidine SCHEMBL165720 | 0.78 | NOS2 (0.42) | — | |
| Guanidine SCHEMBL2003 | 0.78 | — | — | |
| Guanidine SCHEMBL11330173 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2975409-B1 | ZANAMIVIR PHOSPHONATE CONGENERS WITH ANTI-INFLUENZA ACTIVITY AND DETERMINING OSELTAMIVIR SUSCEPTIBILITY OF INFLUENZA VIRUSES | ACADEMIA SINICA (TW) | 2018-10-31 | — | — | EP | claimed |
| US-9874562-B2 | Zanamivir phosphonate congeners with anti-influenza activity and determining oseltamivir susceptibility of influenza viruses | ACADEMIA SINICA (TW) | 2018-01-23 | — | — | US | claimed |
| US-20170102387-A1 | ZANAMIVIR PHOSPHONATE CONGENERS WITH ANTI-INFLUENZA ACTIVITY AND DETERMINING OSELTAMIVIR SUSCEPTIBILITY OF INFLUENZA VIRUSES | ACADEMIA SINICA (TW) | 2017-04-13 | — | — | US | claimed |
| EP-2975409-A1 | ZANAMIVIR PHOSPHONATE CONGENERS WITH ANTI-INFLUENZA ACTIVITY AND DETERMINING OSELTAMIVIR SUSCEPTIBILITY OF INFLUENZA VIRUSES | Academia Sinica (TW) | 2016-01-20 | — | — | EP | claimed |
| CN-104777301-A | Zanamivir phosphonate congeners with anti-influenza activity and determination of oseltamivir susceptibility of influenza viruses | ACADEMIA SINICA | 2015-07-15 | — | — | CN | claimed |
| US-20130225532-A1 | ZANAMIVIR PHOSPHONATE CONGENERS WITH ANTI-INFLUENZA ACTIVITY AND DETERMINING OSELTAMIVIR SUSCEPTIBILITY OF INFLUENZA VIRUSES | ACADEMIA SINICA (TW) | 2013-08-29 | — | — | US | claimed |
| CN-103068378-A | Zanamivir phosphonate congeners with anti-influenza activity and determination of oseltamivir susceptibility of influenza viruses | ACADEMIA SINICA | 2013-04-24 | — | — | CN | claimed |
| EP-2568976-A2 | ZANAMIVIR PHOSPHONATE CONGENERS WITH ANTI-INFLUENZA ACTIVITY AND DETERMINING OSELTAMIVIR SUSCEPTIBILITY OF INFLUENZA VIRUSES | Academia Sinica (TW) | 2013-03-20 | — | — | EP | claimed |
| WO-2011143262-A2 | ZANAMIVIR PHOSPHONATE CONGENERS WITH ANTI-INFLUENZA ACTIVITY AND DETERMINING OSELTAMIVIR SUSCEPTIBILITY OF INFLUENZA VIRUSES | SINICA, ACADEMIA (TW) | 2011-11-17 | — | — | WO | claimed |
| CN-116004509-A | Tissue engineering skin with multilayer epidermal cells and preparation method and application thereof | 中国科学院理化技术研究所 | 2023-04-25 | — | — | CN | disclosed |
| EP-2975409-B1 | ZANAMIVIR PHOSPHONATE CONGENERS WITH ANTI-INFLUENZA ACTIVITY AND DETERMINING OSELTAMIVIR SUSCEPTIBILITY OF INFLUENZA VIRUSES | ACADEMIA SINICA (TW) | 2018-10-31 | — | — | EP | disclosed |
| CN-104777301-B | Zanamivir phosphonate congeners with anti-influenza activity and determination of oseltamivir susceptibility of influenza viruses | 中央研究院 | 2018-04-20 | — | — | CN | disclosed |
| US-9874562-B2 | Zanamivir phosphonate congeners with anti-influenza activity and determining oseltamivir susceptibility of influenza viruses | ACADEMIA SINICA (TW) | 2018-01-23 | — | — | US | disclosed |
| US-20170102387-A1 | ZANAMIVIR PHOSPHONATE CONGENERS WITH ANTI-INFLUENZA ACTIVITY AND DETERMINING OSELTAMIVIR SUSCEPTIBILITY OF INFLUENZA VIRUSES | ACADEMIA SINICA (TW) | 2017-04-13 | — | — | US | disclosed |
| CN-104777301-A | Zanamivir phosphonate congeners with anti-influenza activity and determination of oseltamivir susceptibility of influenza viruses | ACADEMIA SINICA | 2015-07-15 | — | — | CN | disclosed |
| CN-104530413-A | Biologically related substances modified by multifunctional H-type polyethylene glycol derivative | XIAMEN SINOPEG BIOTECH INC | 2015-04-22 | — | — | CN | disclosed |
| US-20130225532-A1 | ZANAMIVIR PHOSPHONATE CONGENERS WITH ANTI-INFLUENZA ACTIVITY AND DETERMINING OSELTAMIVIR SUSCEPTIBILITY OF INFLUENZA VIRUSES | ACADEMIA SINICA (TW) | 2013-08-29 | — | — | US | disclosed |
| CN-103068378-A | Zanamivir phosphonate congeners with anti-influenza activity and determination of oseltamivir susceptibility of influenza viruses | ACADEMIA SINICA | 2013-04-24 | — | — | CN | disclosed |
| EP-2568976-A2 | ZANAMIVIR PHOSPHONATE CONGENERS WITH ANTI-INFLUENZA ACTIVITY AND DETERMINING OSELTAMIVIR SUSCEPTIBILITY OF INFLUENZA VIRUSES | Academia Sinica (TW) | 2013-03-20 | — | — | EP | disclosed |
| WO-2011143262-A2 | ZANAMIVIR PHOSPHONATE CONGENERS WITH ANTI-INFLUENZA ACTIVITY AND DETERMINING OSELTAMIVIR SUSCEPTIBILITY OF INFLUENZA VIRUSES | SINICA, ACADEMIA (TW) | 2011-11-17 | — | — | WO | disclosed |