Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | PDK2 | Q15119 | 5/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | ERN1 | O75460 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PDK4 | Q16654 | 4/20 | 0.40 |
| ▸ | PDK1 | Q15118 | 3/20 | 0.40 |
| ▸ | PDK3 | Q15120 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1004649 | 0.83 | ALDH1A1 (0.73) | HPGDALDH1A1SMN1; SMN2PDK2HSP90AA1 | |
| SCHEMBL24783913 | 0.82 | ALDH1A1 (0.67) | HPGDALDH1A1SMN1; SMN2PDK2HSP90AA1 | |
| SCHEMBL19663875 | 0.80 | NPC1 (0.55) | HPGDALDH1A1SMN1; SMN2MAPTMEN1 | |
| SCHEMBL20003185 | 0.80 | MAPT (0.55) | HPGDALDH1A1SMN1; SMN2MAPTMEN1 | |
| SCHEMBL643967 | 0.77 | ALDH1A1 (0.59) | HPGDALDH1A1SMN1; SMN2PDK2HSP90AA1 | |
| SCHEMBL19601225 | 0.77 | MAPT (0.79) | HPGDALDH1A1SMN1; SMN2MAPTMEN1 | |
| SCHEMBL14293288 | 0.77 | NOTUM (0.59) | HPGDALDH1A1SMN1; SMN2MAPTMEN1 | |
| SCHEMBL10626283 | 0.77 | ALDH1A1 (0.64) | HPGDALDH1A1SMN1; SMN2PDK2MAPT | |
| SCHEMBL17681603 | 0.75 | HPGD (0.52) | HPGDALDH1A1SMN1; SMN2PDK2HSP90AA1 | |
| SCHEMBL1300109 | 0.75 | ALDH1A1 (0.61) | HPGDALDH1A1SMN1; SMN2PDK2HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230301984-A1 | CYCLIC COMPOUNDS FOR USE IN TREATING RETINAL DEGENERATION | THE USA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2023-09-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230301984-A1 | CYCLIC COMPOUNDS FOR USE IN TREATING RETINAL DEGENERATION | ALDH1A2, PDE6D, PDE6C | HPGD 401/4885ALDH1A1 145/4885SMN1; SMN2 107/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.