Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR3 | Q99500 | 16/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 9/20 | 0.36 |
| ▸ | S1PR2 | O95136 | 7/20 | 0.36 |
| ▸ | LPAR2 | Q9HBW0 | 3/20 | 0.36 |
| ▸ | S1PR4 | O95977 | 4/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.33 |
| ▸ | SPNS2 | Q8IVW8 | 1/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL35951 | 0.86 | S1PR3 (0.63) | S1PR3S1PR1S1PR2LPAR2S1PR4 | |
| SCHEMBL36123 | 0.69 | S1PR3 (0.66) | S1PR3S1PR1S1PR2LPAR2S1PR4 | |
| SCHEMBL36337 | 0.68 | S1PR3 (0.87) | S1PR3S1PR1S1PR2LPAR2S1PR4 | |
| SCHEMBL13279803 | 0.68 | S1PR1 (0.43) | S1PR3S1PR1S1PR2LPAR2S1PR4 | |
| SCHEMBL35933 | 0.67 | S1PR3 (0.67) | S1PR3S1PR1S1PR2LPAR2S1PR4 | |
| SCHEMBL27939769 | 0.67 | HTR5A (0.41) | S1PR3S1PR1S1PR2LPAR2S1PR4 | |
| SCHEMBL27939768 | 0.67 | HTR5A (0.41) | S1PR3S1PR1S1PR2LPAR2S1PR4 | |
| SCHEMBL19217017 | 0.59 | S1PR1 (0.73) | S1PR3S1PR1S1PR2LPAR2S1PR4 | |
| SCHEMBL6736726 | 0.59 | HSD17B10 (0.55) | KDM4EMEN1USP2ALDH1A1GAA | |
| SCHEMBL10462640 | 0.59 | MAPT (0.55) | KDM4EMEN1USP2ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2569322-A1 | AROMATIC COMPOUNDS HAVING SPHINGOSINE-1-PHOSPHONATE (S1P) RECEPTOR ACTIVITY | Allergan, Inc. (US) | 2013-03-20 | — | — | EP | disclosed |
| WO-2011143332-A1 | AROMATIC COMPOUNDS HAVING SPHINGOSINE-1-PHOSPHONATE (S1P) RECEPTOR ACTIVITY | ALLERGAN, INC. (US) | 2011-11-17 | — | — | WO | disclosed |