Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ORAI1 | Q96D31 | 3/20 | 0.52 |
| ▸ | ORAI2 | Q96SN7 | 3/20 | 0.52 |
| ▸ | ORAI3 | Q9BRQ5 | 3/20 | 0.52 |
| ▸ | TRPV6 | Q9H1D0 | 3/20 | 0.52 |
| ▸ | CA4 | P22748 | 2/20 | 0.41 |
| ▸ | CA6 | P23280 | 1/20 | 0.41 |
| ▸ | CA5A | P35218 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.41 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22578257 | 0.85 | ORAI1 (0.44) | ORAI1ORAI2ORAI3TRPV6CA4 | |
| SCHEMBL28243261 | 0.79 | ORAI1 (0.39) | ORAI1ORAI2ORAI3TRPV6CA4 | |
| SCHEMBL28054483 | 0.77 | ORAI1 (0.68) | ORAI1ORAI2ORAI3TRPV6CA4 | |
| Benzene SCHEMBL28042387 | 0.72 | TRPV6 (0.50) | ORAI1ORAI2ORAI3TRPV6CA4 | |
| SCHEMBL244920 | 0.72 | TRPV6 (0.50) | ORAI1ORAI2ORAI3TRPV6CA4 | |
| SCHEMBL6677524 | 0.71 | ORAI1 (0.46) | ORAI1ORAI2ORAI3TRPV6CA4 | |
| SCHEMBL1221793 | 0.71 | TRPV6 (0.46) | ORAI1ORAI2ORAI3TRPV6CA4 | |
| SCHEMBL309077 | 0.71 | CA4 (0.48) | ORAI1ORAI2ORAI3TRPV6CA4 | |
| SCHEMBL2744416 | 0.71 | ORAI1 (0.46) | ORAI1ORAI2ORAI3TRPV6CA4 | |
| SCHEMBL28565346 | 0.71 | TRPV6 (0.48) | ORAI1ORAI2ORAI3TRPV6CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 277 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114736414-A | Preparation method of hydrophilic polystyrene microspheres | 南京亘闪生物科技有限公司 | 2022-07-12 | — | — | CN | claimed |
| CN-111171721-A | Ceramizable ablation-resistant coating and preparation method thereof | 西安近代化学研究所 | 2020-05-19 | — | — | CN | claimed |
| US-8921299-B2 | Detergents having acceptable color | THE PROCTER & GAMBLE COMPANY (US) | 2014-12-30 | — | — | US | claimed |
| US-20240247382-A1 | Surrogate Electrolyzers Producing Hydrogen and an Arbitrage of Urea, Formamide, Ammonia and Methanol | PAPILE CHRISTOPHER (US) | 2024-07-25 | — | — | US | disclosed |
| WO-2024126697-A1 | HIGH STRENGTH LIQUID PROTEASE FORMULATIONS | NOVOZYMES A/S (DK) | 2024-06-20 | — | — | WO | disclosed |
| EP-4379029-A1 | POLYPEPTIDES AND COMPOSITIONS COMPRISING SUCH POLYPEPTIDES | Novozymes A/S (DK) | 2024-06-05 | — | — | EP | disclosed |
| EP-3647398-B1 | CLEANING COMPOSITIONS CONTAINING DISPERSINS V | HENKEL AG & CO KGAA (DE) | 2024-05-15 | — | — | EP | disclosed |
| US-20240132808-A1 | Storage-Stable Hydrolase Containing Liquids | BASF SE (DE) | 2024-04-25 | — | — | US | disclosed |
| CN-117904083-A | Protease variants and polynucleotides encoding same | 诺维信公司 | 2024-04-19 | — | — | CN | disclosed |
| EP-4305146-A1 | POLYPEPTIDE VARIANTS | Novozymes A/S (DK) | 2024-01-17 | — | — | EP | disclosed |
| US-20240010955-A1 | Polypeptides and Compositions Comprising Such Polypeptides | NOVOZYMES A/S (DK) | 2024-01-11 | — | — | US | disclosed |
| US-6608063-B2 | For example: (2-(3-amino-4-nitrophenyl)amino)ethyl)(6-(2,4-dichlorophenyl-5-nitropyrazin -2-yl)-amine; antidiabetic, -carcingenic and ischemic agents; nervous and cardiovascular system disorders; immunotherapy; obesity; syndromes | CHIRON CORPORATION | 2003-08-19 | — | — | US | disclosed |
| WO-2003045924-A1 | SUBSTITUTED ARYL 1,4-PYRAZINE DERIVATIVES | PHARMACIA & UPJOHN COMPANY (US) | 2003-06-05 | — | — | WO | disclosed |
| WO-2003009689-A1 | METHODS AND COMPOSITIONS FOR TREATING FUNGAL INFECTIONS | RAMOT AT TEL AVIV UNIVERSITY LTD. (IL) | 2003-02-06 | — | — | WO | disclosed |
| EP-1237880-A2 | PYRAZINE BASED INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 2002-09-11 | — | — | EP | disclosed |
| WO-2001044206-A9 | PYRAZINE BASED INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORP (US) | 2002-05-23 | — | — | WO | disclosed |
| US-20010034051-A1 | Pyrazine based inhibitors of glycogen synthase kinase 3 | CHIRON CORPORATION | 2001-10-25 | — | — | US | disclosed |
| WO-2001044206-A1 | PYRAZINE BASED INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 2001-06-21 | — | — | WO | disclosed |
| WO-1995005081-A1 | BIOCIDAL COMPOSITIONS CONTAINING ORGANOBORON COMPOUNDS | U.S. BORAX INC. (US) | 1995-02-23 | — | — | WO | disclosed |
| EP-0478050-A1 | Detergent composition | UNILEVER N.V. (NL) | 1992-04-01 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010034051-A1 | Pyrazine based inhibitors of glycogen synthase kinase 3 | GSK3B, GSK3A, GSKIP | ORAI1 3065/4885ORAI2 3046/4885ORAI3 1564/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.